Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis

source extracted confidence: high 2026-04-09
#humans #catechin #colorectal-neoplasms #neoplasm-recurrence-local #randomized-controlled-trials-as-topic

Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis

He et al., 2024 | Curr Pharm Des | Meta Analysis

Citation

He Benyu, Kang Shuhui, ... Chen Si. Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis. Curr Pharm Des. 2024;30(33):2643-2651. doi:10.2174/0113816128319678240612114820

Abstract

BACKGROUND AND AIMS: The recurrence rate of Colorectal Cancer (CRC) after cure is always high. The purpose of this study was to investigate whether green tea extract (-)-Epigallocatechin gallate (EGCG) has an effective preventive effect on the recurrence of CRC. METHODS: We conducted a systematic literature review and meta-analysis of the effects of taking EGCG or placebo on disease recurrence in patients after colon polyp removal. RESULTS: Five Randomized Controlled Trials (RCTs) were included in this review. A double-blind drug trial involving 1389 participants involved EGCG and placebo. The results showed no significant publication bias or heterogeneity in the five studies (I2 = 38%; p = 0.17). Patients taking EGCG had a lower recurrence rate of CRC than those in the placebo group. The results were statistically significant (Z=2.83, p < 0.05). CONCLUSION: This study demonstrated that long-term EGCG can prevent CRC recurrence to a certain extent.

Key Findings

Five Randomized Controlled Trials (RCTs) were included in this review. A double-blind drug trial involving 1389 participants involved EGCG and placebo. The results showed no significant publication bias or heterogeneity in the five studies (I2 = 38%; p = 0.17). Patients taking EGCG had a lower recurrence rate of CRC than those in the placebo group. The results were statistically significant (Z=2.83, p < 0.05).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 1389
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Catechin
  • Colorectal Neoplasms
  • Neoplasm Recurrence, Local
  • Randomized Controlled Trials as Topic
  • Tea

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: green-tea

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09