Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#melatonin #humans #female #pregnancy #pregnancy-rate

Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis

Veiga et al., 2024 | Clinics (Sao Paulo) | Meta Analysis

Citation

Veiga Eduardo Carvalho de Arruda, Samama Marise, ... Junior Jose Maria Soares. Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis. Clinics (Sao Paulo). 2024;79:100397. doi:10.1016/j.clinsp.2024.100397

Abstract

BACKGROUND: Melatonin is a hormone produced by the pineal gland and it has antioxidant properties. AIM: This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis. MATERIALS AND METHODS: Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes. RESULTS: The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001). CONCLUSIONS: Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.

Key Findings

The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Melatonin
  • Humans
  • Female
  • Pregnancy
  • Pregnancy Rate
  • Reproductive Techniques, Assisted
  • Antioxidants
  • Fertilization in Vitro
  • Pregnancy Outcome
  • Fertilization

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: melatonin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09