Role of omega-3 fatty acids in reducing proteinuria: A systematic review and meta-analysis

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#fatty-acids-omega-3 #humans #proteinuria #dietary-supplements #renal-insufficiency-chronic

Role of omega-3 fatty acids in reducing proteinuria: A systematic review and meta-analysis

Fei et al., 2024 | Asia Pac J Clin Nutr | Meta Analysis

Citation

Fei Liangyu, Huang Rizhen, Li Zhong. Role of omega-3 fatty acids in reducing proteinuria: A systematic review and meta-analysis. Asia Pac J Clin Nutr. 2024-Sep;33(3):313-318. doi:10.6133/apjcn.202409_33(3).0003

Abstract

BACKGROUND AND OBJECTIVES: Proteinuria, a hallmark of renal and systemic disorders, is associated with adverse outcomes, especially in chronic kidney disease and cardiovascular disease. Omega-3 fatty acids have garnered attention for their cardiovascular benefits and potential therapeutic effects on proteinuria. This systematic review and meta-analysis aimed to evaluate the impact of omega-3 fatty acid supplementation on proteinuria levels across various kidney-related conditions. METHODS AND STUDY DESIGN: Studies published from 1989 to 2023 were systematically identified, including randomized controlled trials, cohort, case-control, and cross-sectional studies. Nine studies involving a total of 347 participants were included in the analysis. RESULTS: The meta-analysis revealed a neutral overall effect size of omega-3 fatty acid supplementation on proteinuria levels, assessed under both common and random effect models. Despite the lack of statistically significant evidence supporting the efficacy of omega-3 fatty acids in reducing proteinuria, the variability in interventions and patient populations suggests potential individual responses. CONCLUSIONS: The find-ings highlight the heterogeneity in responses to omega-3 fatty acid supplementation and emphasize the need for cautious interpretation. While no definitive conclusion can be drawn, the results underscore the importance of targeted research focusing on specific subgroups or conditions that may benefit from omega-3 supplementation. These findings contribute to the evolving understanding of personalized kidney health strategies and pave the way for further exploration and optimization of omega-3 fatty acids' therapeutic applications.

Key Findings

The meta-analysis revealed a neutral overall effect size of omega-3 fatty acid supplementation on proteinuria levels, assessed under both common and random effect models. Despite the lack of statistically significant evidence supporting the efficacy of omega-3 fatty acids in reducing proteinuria, the variability in interventions and patient populations suggests potential individual responses.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 347
Age Range See abstract
Condition See abstract

MeSH Terms

  • Fatty Acids, Omega-3
  • Humans
  • Proteinuria
  • Dietary Supplements
  • Renal Insufficiency, Chronic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09