Extraction, purification, structural characterization, and bioactivities of the genus Rhodiola L. polysaccharides: A review

source extracted confidence: high 2026-04-09
#anti-inflammatory-agents #antioxidants #molecular-weight #monosaccharides #plant-extracts

Extraction, purification, structural characterization, and bioactivities of the genus Rhodiola L. polysaccharides: A review

Gan et al., 2024 | Int J Biol Macromol | Systematic Review

Citation

Gan Zhengkun, Fang Xiao, ... Tao Aien. Extraction, purification, structural characterization, and bioactivities of the genus Rhodiola L. polysaccharides: A review. Int J Biol Macromol. 2024-Sep;276(Pt 1):133614. doi:10.1016/j.ijbiomac.2024.133614

Abstract

The genus Rhodiola L., an integral part of traditional Chinese medicine and Tibetan medicine in China, exhibits a broad spectrum of applications. This genus contains key compounds such as ginsenosides, polysaccharides, and flavonoids, which possess anti-inflammatory, antioxidant, hypoglycaemic, immune-enhancing, and anti-hypoxic properties. As a vital raw material, Rhodiola L. contributes to twenty-four kinds of Chinese patent medicines and 481 health food products in China, finding extensive application in the health food sector. Recently, polysaccharides have emerged as a focal point in natural product research, with applications spanning the medicine, food, and materials sectors. Despite this, a comprehensive and systematic review of polysaccharides from the genus Rhodiola L. polysaccharides (TGRPs) is warranted. This study undertakes a systematic review of both domestic and international literature, assessing the research advancements and chemical functional values of polysaccharides derived from Rhodiola rosea. It involves the isolation, purification, and identification of a variety of homogeneous polysaccharides, followed by a detailed analysis of their chemical structures, pharmacological activities, and molecular mechanisms, structure-activity relationship (SAR) of TGRPs. The discussion includes the influence of molecular weight, monosaccharide composition, and glycosidic bonds on their biological activities, such as sulfation and carboxymethylation et al. Such analyses are crucial for deepening the understanding of Rhodiola rosea and for fostering the development and exploitation of TGRPs, offering a reference point for further investigations into TGRPs and their resource utilization.

Key Findings

Such analyses are crucial for deepening the understanding of Rhodiola rosea and for fostering the development and exploitation of TGRPs, offering a reference point for further investigations into TGRPs and their resource utilization.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Anti-Inflammatory Agents
  • Antioxidants
  • Molecular Weight
  • Monosaccharides
  • Plant Extracts
  • Polysaccharides
  • Rhodiola
  • Structure-Activity Relationship

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: rhodiola

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09