Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials

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#humans #aloe #anti-bacterial-agents #anti-inflammatory-agents #antioxidants

Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials

Talpos et al., 2024 | Nutrients | Systematic Review

Citation

Talpos Niculescu Serban, Avramut Robert, ... Popa Malina. Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials. Nutrients. 2024-Jun-19;16(12). doi:10.3390/nu16121941

Abstract

The use of natural products as alternatives to traditional pharmacological treatments in orthodontics is gaining interest due to their anti-inflammatory, antibacterial, and antioxidant properties. This systematic review synthesizes evidence from clinical trials to evaluate the efficacy of natural products in reducing inflammation and bacterial presence in orthodontic and orthognathic treatment settings. The database search was conducted across PubMed, Scopus, and Embase up to January 2024. The review focused on randomized controlled trials only. The selected studies centered on the anti-inflammatory, antibacterial, and antioxidant effects of natural products, adhering to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines for data extraction. Nine studies, totaling 358 participants, were included. Significant findings demonstrated a reduction in gingival inflammation by over 40% with the use of Aloe vera compared to chlorhexidine. Another study noted a decrease in bleeding on probing by 13.6 points in the treatment group over placebo. Additionally, honey showed a rapid modulation of plaque pH and significantly reduced bacterial counts of Streptococcus mutans. Furthermore, the use of resveratrol emulgel was linked to substantial improvements in gingival health, with a reduction in the gingival index and probing pocket depth. The results indicate that natural products can significantly enhance orthodontic treatment outcomes by reducing inflammation and bacterial levels. These products offer effective alternatives to traditional treatments and show potential for integration into routine orthodontic care protocols. Further research is encouraged to standardize application methods and dosages to maximize clinical benefits and patient satisfaction.

Key Findings

Further research is encouraged to standardize application methods and dosages to maximize clinical benefits and patient satisfaction.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 358
Age Range See abstract
Condition inflammation

MeSH Terms

  • Humans
  • Aloe
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Antioxidants
  • Biological Products
  • Chlorhexidine
  • Dentofacial Deformities
  • Gingivitis
  • Honey
  • Orthodontics
  • Plant Preparations
  • Randomized Controlled Trials as Topic
  • Resveratrol
  • Streptococcus mutans
  • Treatment Outcome

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09