Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies

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#cymenes #mycobacterium #microbial-sensitivity-tests #anti-bacterial-agents #humans

Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies

Fermiano et al., 2024 | Future Med Chem | Systematic Review

Citation

Fermiano Thiago H, Perez de Souza João V, ... Cardoso Rosilene Fressatti. Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies. Future Med Chem. 2024-Apr;16(7):679-688. doi:10.4155/fmc-2023-0249

Abstract

Background: The scope of the study was to analyze original preclinical studies on the antimicrobial effects of carvacrol and derivatives on the Mycobacterium genus. Materials & methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, four databases (PubMed, Web of Science, SCOPUS and EMBASE) were searched. Results: The search retrieved 392 records, of which 11 papers were selected. Heterogeneity in the techniques and mycobacterial targets was observed. Carvacrol demonstrated synergistic antimycobacterial activity with rifampicin against multidrug-resistant Mycobacterium tuberculosis on membranes and biofilms. In silico approaches showed specific targets in mycobacteria, by inhibition and molecular docking assays, on the enzyme chorismate mutase and the heat shock protein 16.3. Conclusion: Carvacrol has been shown to be a scaffold candidate for future molecules with activity against mycobacteria.

Key Findings

The search retrieved 392 records, of which 11 papers were selected. Heterogeneity in the techniques and mycobacterial targets was observed. Carvacrol demonstrated synergistic antimycobacterial activity with rifampicin against multidrug-resistant Mycobacterium tuberculosis on membranes and biofilms. In silico approaches showed specific targets in mycobacteria, by inhibition and molecular docking assays, on the enzyme chorismate mutase and the heat shock protein 16.3. Conclusion: Carvacrol has bee

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cymenes
  • Mycobacterium
  • Microbial Sensitivity Tests
  • Anti-Bacterial Agents
  • Humans
  • Molecular Docking Simulation
  • Mycobacterium tuberculosis
  • Antitubercular Agents

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: oregano-oil

Provenance

Source extracted via PubMed E-utilities API on 2026-04-12