Vitamin intake and periodontal disease: a meta-analysis of observational studies

source extracted confidence: high 2026-04-09
#humans #ascorbic-acid #folic-acid #periodontal-diseases #vitamin-a

Vitamin intake and periodontal disease: a meta-analysis of observational studies

Mi et al., 2024 | BMC Oral Health | Meta Analysis

Citation

Mi Nannan, Zhang Miaomiao, ... Jin Ying. Vitamin intake and periodontal disease: a meta-analysis of observational studies. BMC Oral Health. 2024-Jan-20;24(1):117. doi:10.1186/s12903-024-03850-5

Abstract

OBJECTIVE: A meta-analysis was performed to assess the epidemiological correlation between dietary intake of various types of vitamin intake and the risk of periodontal disease. METHODS: A comprehensive computerized search was conducted in eight databases, namely PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine Disc, CNKI, VIP, and WanFang Database, and a random effect model was applied to combine pooled odds ratio (ORs) with corresponding 95% confidence intervals (CIs) of the included studies, and the sensitivity analysis was performed to explore the impact of a single study on the comprehensive results. RESULTS: We finally included 45 effect groups from 23 observational studies, with a total number of study participants of 74,488. The results showed that higher levels of vitamin A (OR: 0.788, 95% CI: 0.640-0.971), vitamin B complex (OR: 0.884, 95% CI: 0.824-0.948), vitamin C (OR: 0.875, 95% CI: 0.775-0.988), vitamin D (OR: 0.964, 95% CI: 0.948-0.981), and vitamin E (OR: 0.868, 95% CI: 0.776-0.971) intake all were negatively correlated with periodontal disease. After removing each study, leave-one-out sensitivity analysis indicated no significant change in the overall results of any of the five meta-analyses. CONCLUSIONS: The results from this meta-analysis demonstrated a negative association between high-dose vitamin A, vitamin B complex, vitamin C, vitamin D, and vitamin E consumption and the likelihood of developing periodontal disease, revealing the significant role of vitamins in preventing periodontal disease.

Key Findings

We finally included 45 effect groups from 23 observational studies, with a total number of study participants of 74,488. The results showed that higher levels of vitamin A (OR: 0.788, 95% CI: 0.640-0.971), vitamin B complex (OR: 0.884, 95% CI: 0.824-0.948), vitamin C (OR: 0.875, 95% CI: 0.775-0.988), vitamin D (OR: 0.964, 95% CI: 0.948-0.981), and vitamin E (OR: 0.868, 95% CI: 0.776-0.971) intake all were negatively correlated with periodontal disease. After removing each study, leave-one-out se

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 45
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Ascorbic Acid
  • Folic Acid
  • Periodontal Diseases
  • Vitamin A
  • Vitamin B Complex
  • Vitamin D
  • Vitamin E

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Journal Article
  • Vertical: vitamin-a

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09