Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis

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#adult #adolescent #humans #child #cystic-fibrosis

Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis

Farahbakhsh et al., 2024 | J Health Popul Nutr | Meta Analysis

Citation

Farahbakhsh Nazanin, Fatahi Somaye, ... Hosseini Amir Hossein. Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis. J Health Popul Nutr. 2024-Jan-17;43(1):11. doi:10.1186/s41043-024-00499-2

Abstract

AIM: Vitamin D is a prominent modulator of immunity and respiratory function. It plays a vital role in respiratory diseases such as cystic fibrosis (CF). S. However, there is a dearth of information on patients with CF. The purpose of the meta-analysis is to highlight the importance of following the existing guidelines regarding maintenance of Vitamin D serum levels in patients with CF. METHODS: The systematic search was conducted without utilizing any time or language limitations in original database from the beginning until March 2022. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I2 statistics and Cochrane Q test. RESULTS: Pooled analysis using the random-effects model of the 8 case-control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescences (WMD: - 3.41 ng/ml, 95% CI - 5.02, - 1.80, p =  < 0.001) and adults (WMD: - 2.60 ng/ml, 95% CI - 4.32, - 0.89, p = 0.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20-30 ng/ml in CF patients was 36% among pediatrics/adolescents and 63% among adults. In addition, 27% of pediatric/adolescent CF patients and 35% of adult CF patients had vitamin D levels of below 20 ng/ml. CONCLUSIONS: As a result, according to the existing guidelines, our results proved the need to pay attention to the level of vitamin D in these patients.

Key Findings

Pooled analysis using the random-effects model of the 8 case-control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescences (WMD: - 3.41 ng/ml, 95% CI - 5.02, - 1.80, p =  < 0.001) and adults (WMD: - 2.60 ng/ml, 95% CI - 4.32, - 0.89, p = 0.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20-30 ng/ml

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population adult cf
Sample Size 1622
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Adolescent
  • Humans
  • Child
  • Cystic Fibrosis
  • Vitamin D Deficiency
  • Vitamin D
  • Case-Control Studies

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09