Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis

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#humans #vitamin-d #female #dietary-supplements #biomarkers

Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis

Nasimi et al., 2024 | Br J Nutr | Meta Analysis

Citation

Nasimi Nasrin, Jamshidi Sanaz, ... Faghih Shiva. Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis. Br J Nutr. 2024-May-14;131(9):1473-1487. doi:10.1017/S0007114524000060

Abstract

Vitamin D is a vital indicator of musculoskeletal health, as it plays an important role through the regulation of bone and mineral metabolism. This meta-analysis was performed to investigate the effects of vitamin D supplementation/fortification on bone turnover markers in women. All human randomised clinical trials reported changes in bone resorption markers (serum C-terminal telopeptide of type-I collagen (sCTX) and urinary type I collagen cross-linked N-telopeptide (uNTX)) or bone formation factors (osteocalcin (OC), bone alkaline phosphatase (BALP) and procollagen type-1 intact N-terminal propeptide (P1NP)) following vitamin D administration in women (aged ≥ 18 years) were considered. Mean differences (MD) and their respective 95 % CI were calculated based on fixed or random effects models according to the heterogeneity status. Subgroup analyses, meta-regression models, sensitivity analysis, risk of bias, publication bias and the quality of the included studies were also evaluated. We found that vitamin D supplementation had considerable effect on sCTX (MD: -0·038, n 22) and OC (MD: -0·610, n 24) with high heterogeneity and uNTX (MD: -8·188, n 6) without heterogeneity. Our results showed that age, sample size, dose, duration, baseline vitamin D level, study region and quality of studies might be sources of heterogeneity in this meta-analysis. Subgroup analysis also revealed significant reductions in P1NP level in dose less than 600 μg/d and larger study sample size (>100 participants). Moreover, no significant change was found in BALP level. Vitamin D supplementation/fortification significantly reduced bone resorption markers in women. However, results were inconsistent for bone formation markers.

Key Findings

However, results were inconsistent for bone formation markers.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 100
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Vitamin D
  • Female
  • Dietary Supplements
  • Biomarkers
  • Bone Remodeling
  • Randomized Controlled Trials as Topic
  • Bone Resorption
  • Collagen Type I
  • Bone and Bones
  • Osteocalcin
  • Alkaline Phosphatase
  • Peptides
  • Food, Fortified

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis, Research Support, Non-U.S. Gov't
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09