Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review

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#reactive-oxygen-species #biological-products #oxidative-stress #antioxidants #curcuma

Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review

Inchingolo et al., 2023 | Nutrients | Systematic Review

Citation

Inchingolo Francesco, Inchingolo Angelo Michele, ... Dipalma Gianna. Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review. Nutrients. 2023-Dec-28;16(1). doi:10.3390/nu16010113

Abstract

In recent years, orthodontics, a specialized branch of dentistry, has evolved considerably in terms of both techniques and materials used. Aimed at correcting dental malocclusions and craniofacial anomalies, it improves the functionality and aesthetics of the face and oral cavity. However, orthodontic treatment, in its developmental stages, may induce oxidative stress (O.S.) phenomena, with an increase in the production of reactive oxygen species (ROS), damaging the dental and periodontal tissues involved, affecting the short-, medium- and long-term results. Studies on the antioxidant effects of natural products (e.g., resveratrol, green tea, turmeric, etc.) in the medical field have aroused considerable interest in recent years. A systematic literature review was conducted on the PubMed, Scopus, and Web of Science databases using natural products (N.P.s), O.S., and orthodontic as keywords. The study aims to consider the determinants of the increase in ROS occurring during orthodontic treatment and the possibility of natural products being able to control and neutralize biochemical phenomena by restoring the physiological process in which the balance between the production of ROS and the ability of the body's antioxidant system to neutralize them is in favor of the latter.

Key Findings

The study aims to consider the determinants of the increase in ROS occurring during orthodontic treatment and the possibility of natural products being able to control and neutralize biochemical phenomena by restoring the physiological process in which the balance between the production of ROS and the ability of the body's antioxidant system to neutralize them is in favor of the latter.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Reactive Oxygen Species
  • Biological Products
  • Oxidative Stress
  • Antioxidants
  • Curcuma

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09