Clinical outcomes between direct oral anticoagulants versus vitamin K antagonists in chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis
Clinical outcomes between direct oral anticoagulants versus vitamin K antagonists in chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis
Salazar et al., 2024 | Curr Probl Cardiol | Meta Analysis
Citation
Salazar Adolfo Martinez, Panama Gabriel, ... Abela George S. Clinical outcomes between direct oral anticoagulants versus vitamin K antagonists in chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis. Curr Probl Cardiol. 2024-Mar;49(3):102377. doi:10.1016/j.cpcardiol.2024.102377
Abstract
Pulmonary hypertension (PH) is a known chronic condition that can lead to increased morbidity and mortality. Patients who develop PH due to thromboembolic disease are catalogued as chronic thromboembolic pulmonary hypertension (CTEPH). Anticoagulation remains a topic of interest in these patients. PUBMED, EMBASE and COCHRANE databases were searched by two investigators until December 2023. Information was analyzed for all-cause mortality, venous thromboembolism and major bleeding. We included a total of 10 studies in this meta-analysis. Our pooled analysis demonstrated that DOACs were non-inferior in all-cause mortality [OR 0.88, 95 % CI (0.48, 1.61)], venous thromboembolism [OR 1.00, 95 % CI (0.50, 1.98)] and major bleeding [OR 0.78, 95 % CI (0.43, 1.40)] when compared to VKAs. In conclusion, our meta-analysis supports the use of DOACs in patients with CTEPH. Further randomized trials are still needed to confirm our results in terms of safety and mortality.
Key Findings
Further randomized trials are still needed to confirm our results in terms of safety and mortality.
Outcomes Measured
- Requires manual extraction
Population
| Field | Value |
|---|---|
| Population | cteph |
| Sample Size | 10 |
| Age Range | See abstract |
| Condition | hypertension |
MeSH Terms
- Humans
- Hypertension, Pulmonary
- Vitamin K
- Pulmonary Embolism
- Administration, Oral
- Chronic Disease
- Anticoagulants
- Treatment Outcome
- Factor Xa Inhibitors
Evidence Classification
- Level: Meta Analysis
- Publication Types: Meta-Analysis, Systematic Review, Journal Article
- Vertical: vitamin-k
Provenance
- PMID: 38184126
- DOI: 10.1016/j.cpcardiol.2024.102377
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09