Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review

source extracted confidence: high 2026-04-09
#animals #antioxidants #biological-products #diabetes-mellitus #diabetic-nephropathies

Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review

Jiang et al., 2024 | Food Funct | Meta Analysis

Citation

Jiang Yayi, Li Zihan, ... Yan Dawei. Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review. Food Funct. 2024-Jan-02;15(1):12-36. doi:10.1039/d3fo02407e

Abstract

Garlic (Allium sativum L.) is a popular spice that is widely used for food and medicinal purposes and has shown potential effects on diabetic kidney disease (DKD). Nevertheless, systematic preclinical studies are still lacking. In this meta-analysis and systematic review, we evaluated the role and potential mechanisms of action of garlic and its derived components in animal models of DKD. We searched eight databases for relevant studies from the establishment of the databases to December 2022 and updated in April 2023 before the completion of this review. A total of 24 trials were included in the meta-analysis. It provided preliminary evidence that supplementing with garlic could improve the indicators of renal function (BUN, Scr, 24 h urine volume, proteinuria, and KI) and metabolic disorders (BG, insulin, and body weight). Meanwhile, the beneficial effects of garlic and its components in DKD could be related to alleviating oxidative stress, suppressing inflammatory reactions, delaying renal fibrosis, and improving glucose metabolism. Furthermore, time-dose interval analysis exhibited relatively greater effectiveness when garlic products were supplied at doses of 500 mg kg-1 with interventions lasting 8-10 weeks, and garlic components were administered at doses of 45-150 mg kg-1 with interventions lasting 4-10 weeks. This meta-analysis and systematic review highlights for the first time the therapeutic potential of garlic supplementation in animal models of DKD and offers a more thorough evaluation of its effects and mechanisms to establish an evidence-based basis for designing future clinical trials.

Key Findings

This meta-analysis and systematic review highlights for the first time the therapeutic potential of garlic supplementation in animal models of DKD and offers a more thorough evaluation of its effects and mechanisms to establish an evidence-based basis for designing future clinical trials.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 24
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Antioxidants
  • Biological Products
  • Diabetes Mellitus
  • Diabetic Nephropathies
  • Dietary Supplements
  • Garlic
  • Oxidative Stress
  • Disease Models, Animal

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: garlic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09