Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies

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#animals #alzheimer-disease #neurodegenerative-diseases #oxidative-stress #amyloid-beta-peptides

Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies

Zhang et al., 2023 | J Agric Food Chem | Meta Analysis

Citation

Zhang Nan, Nao Jianfei, Dong Xiaoyu. Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies. J Agric Food Chem. 2023-Nov-22;71(46):17597-17614. doi:10.1021/acs.jafc.3c06672

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and behavioral impairment. Salidroside (Sal) is a phenylpropanoid mainly isolated from Rhodiola species with various pharmacological effects. However, the exact anti-AD mechanism of Sal has not been clearly elucidated. This meta-analysis aims to investigate the possible mechanisms by which Sal exerts its anti-AD effects by evaluating behavioral indicators and biochemical characteristics. A total of 20 studies were included, and the results showed that the Sal treatment significantly improved behavior abnormalities in AD animal models. With regard to neurobiochemical indicators, Sal treatment could effectively increase the antioxidant enzyme superoxide dismutase, decrease the oxidative stress indicator malondialdehyde, and decrease the inflammatory indicators interleukin 1β, interleukin 6, and tumor necrosis factor α. Sal treatment was effective in reducing neuropathological indicators, such as amyloid-β levels and the number of apoptotic cells. When the relevant literature on the treatment of rodent AD models is combined with Sal, the therapeutic potential of Sal through multiple mechanisms was confirmed. However, further confirmation by higher quality studies, larger sample sizes, and more comprehensive outcome evaluations in clinical trials is needed in the future.

Key Findings

However, further confirmation by higher quality studies, larger sample sizes, and more comprehensive outcome evaluations in clinical trials is needed in the future.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 20
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Alzheimer Disease
  • Neurodegenerative Diseases
  • Oxidative Stress
  • Amyloid beta-Peptides
  • Neuroprotective Agents
  • Glucosides
  • Phenols

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: rhodiola

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09