Clinical impacts of n-3 fatty acids supplementation on depression symptoms: an umbrella review of meta-analyses

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Clinical impacts of n-3 fatty acids supplementation on depression symptoms: an umbrella review of meta-analyses

Lu et al., 2024 | Br J Nutr | Systematic Review

Citation

Lu Yi, Qiao Dongdong, Mi Guolin. Clinical impacts of n-3 fatty acids supplementation on depression symptoms: an umbrella review of meta-analyses. Br J Nutr. 2024-Mar-14;131(5):841-850. doi:10.1017/S000711452300226X

Abstract

Several meta-analyses investigating the efficacy of n-3 PUFA in alleviating depression symptoms have reported conflicting findings. In the present study, we aimed to perform an umbrella meta-analysis to provide a definite conclusion. A comprehensive systematic search of PubMed, Scopus, Embase, Web of Science and Cochrane Central Library was performed up to June 2021. Meta-analysis studies evaluating the effects of n-3 PUFA on depression symptoms were included. The quality of the included meta-analyses was assessed using AMSTAR questionnaire. Out of 101 studies, twenty-two studies with twenty-six effect sizes (ES) were eligible for inclusion. Sixteen ES showed significant improving effect of n-3 supplementation on depression symptoms among which eleven ES had small ES. The other studies observed no significant effect. Available evidence suggests that n-3 PUFA (EPA, DHA) supplementation could be considered as an effective add-on therapeutic approach in relieving depression symptoms.

Key Findings

Available evidence suggests that n-3 PUFA (EPA, DHA) supplementation could be considered as an effective add-on therapeutic approach in relieving depression symptoms.

Outcomes Measured

  • depression

Population

Field Value
Population See abstract
Sample Size 101
Age Range See abstract
Condition depression

MeSH Terms

  • Female
  • Humans
  • Depression
  • Dietary Supplements
  • Fatty Acids, Omega-3
  • Meta-Analysis as Topic

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09