Biofortification with selenium as an alternative to increase the total phenolic compounds in brassicas: a systematic review and meta-analysis

Kamchen et al., 2024 | J Sci Food Agric | Meta Analysis

Citation

Kamchen Camila Menezes, de Oliveira Fellipe Lopes, ... Morzelle Maressa Caldeira. Biofortification with selenium as an alternative to increase the total phenolic compounds in brassicas: a systematic review and meta-analysis. J Sci Food Agric. 2024-Feb;104(3):1234-1243. doi:10.1002/jsfa.13020

Abstract

The ability of brassicas to accumulate selenium is crucial for their positive effects on health. Selenium improves the immune system and the antioxidant defenses. Selenium biofortification of brassicas has therefore been explored to increase dietary selenium intake in humans. However, the effects of selenium biofortification on bioactive compounds, mainly phenolic compounds, are not clear. So, this systematic review and meta-analysis aimed to answer the question 'What are effects of the biofortification of brassicas with selenium on total phenolic compounds?' Ten studies, which assessed the effect of selenium biofortification on total phenolic compounds, were selected for qualitative synthesis and four studies were included in the meta-analysis after a thorough literature review of the PubMed, Science Direct, and Web of Knowledge databases. The quality of the evidence ranged from high to moderate. The meta-analysis results indicated that the total phenolic compound content was significantly higher (P = 0.002) in the supplemented group but the results showed considerable heterogeneity (P < 0.00001, I2 = 97%) between studies. This systematic review and meta-analysis summarizes the effect of Se biofortification on the increase in the content of total phenolic compounds and it suggests that several factors can affect this relationship. © 2023 Society of Chemical Industry.

Key Findings

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Humans
Antioxidants
Biofortification
Brassica
Phenols
Selenium

Evidence Classification

Level: Meta Analysis
Publication Types: Meta-Analysis, Systematic Review, Journal Article
Vertical: selenium

Provenance

PMID: 37782303
DOI: 10.1002/jsfa.13020
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09