Protective effects of ginsenosides in cisplatin-induced kidney injury: A systematic review, meta-analysis

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#animals #cisplatin #ginsenosides #kidney #oxidative-stress

Protective effects of ginsenosides in cisplatin-induced kidney injury: A systematic review, meta-analysis

Luo et al., 2023 | Indian J Pharmacol | Meta Analysis

Citation

Luo Xinyi, Xie Dengpiao, ... Ji Qing. Protective effects of ginsenosides in cisplatin-induced kidney injury: A systematic review, meta-analysis. Indian J Pharmacol. 2023;55(4):243-250. doi:10.4103/ijp.ijp_251_23

Abstract

Although evidence suggests ginsenosides, the primary active and distinctive components of ginseng, have beneficial effects in cisplatin-induced nephrotoxicity, their efficacy and protective mechanisms remain unclear. The aim of the current meta-analysis is to study the effectiveness and mechanisms of ginsenosides in a model of nephrotoxicity induced by cisplatin. Preclinical investigations were conducted in the search of various databases including Medline, Web of Science, Google, CNKI, Embase, and the Wanfang database. 12 studies with 216 animals were included in this review. Stata 15.0 and RevMan 5.3 were used for statistical analyses. The pooled results showed that ginsenosides significantly improved kidney function, and inhibited histological damage. The protective mechanism of ginsenosides is associated with its antioxidative stress, anti-inflammation, anti-apoptosis, and anti-autophagy. The results of our study indicate that ginsenosides have the potential to mitigate nephrotoxicity induced by cisplatin through the modulation of various targets and pathways. Consequently, ginsenosides hold promise as therapeutic agents for the clinical management and prevention of cisplatin-induced nephrotoxicity.

Key Findings

Consequently, ginsenosides hold promise as therapeutic agents for the clinical management and prevention of cisplatin-induced nephrotoxicity.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 12
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Cisplatin
  • Ginsenosides
  • Kidney
  • Oxidative Stress

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Systematic Review, Meta-Analysis, Journal Article
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09