Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells

source extracted confidence: high 2026-04-09
#humans #female #matrix-metalloproteinase-2 #matrix-metalloproteinase-9 #taraxacum

Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells

Rezaie et al., 2023 | Sci Rep | Other

Citation

Rezaie Hamed, Alipanah-Moghadam Reza, ... Nemati Ali. Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells. Sci Rep. 2023-Sep-12;13(1):15074. doi:10.1038/s41598-023-42177-z

Abstract

Breast cancer is one of the most prevalent and deadly cancers among women worldwide. Recently, natural compounds have been widely used for the treatment of breast cancer. Present study evaluated antiproliferative and anti-metastasis activities of two natural compounds of dandelion and all-trans-retinoic acid (ATRA) in human MCF-7 and MDA-MB231 breast cancer cells. We also evaluated the expression of MMP-2, MMP-9, IL-1β, p53, NM23 and KAI1 genes. Data showed a clear additive cytotoxic effect in concentrations of 40 μM ATRA with 1.5 and 4 mg/ml of dandelion extract in MCF-7 and MDA-MB231 cells, respectively. In both cell lines, compared with the untreated cells, the expression levels of MMP-9 and IL-1β were significantly decreased while p53 and KAI1 expression levels were increased. Besides, MMP-2 and NM23 had different expressions in the two studied cell lines. In conclusion, dandelion/ATRA co-treatment, in addition to having strong cytotoxic effects, has putative effects on the expression of anti-metastatic genes in both breast cancer cells.

Key Findings

In conclusion, dandelion/ATRA co-treatment, in addition to having strong cytotoxic effects, has putative effects on the expression of anti-metastatic genes in both breast cancer cells.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Female
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
  • Taraxacum
  • Breast Neoplasms
  • Tumor Suppressor Protein p53
  • Tretinoin
  • Plant Extracts

Evidence Classification

  • Level: Other
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't
  • Vertical: dandelion

Provenance

Source extracted via PubMed E-utilities API on 2026-04-12