Supplementing Vitamin D in Different Patient Groups to Reduce Deficiency

source extracted confidence: high 2026-04-09
#humans #vitamin-d #vitamins #vitamin-d-deficiency #knowledge

Supplementing Vitamin D in Different Patient Groups to Reduce Deficiency

Pludowski et al., 2023 | Nutrients | Systematic Review

Citation

Pludowski Pawel. Supplementing Vitamin D in Different Patient Groups to Reduce Deficiency. Nutrients. 2023-Aug-25;15(17). doi:10.3390/nu15173725

Abstract

INTRODUCTION: Studies indicate a high prevalence of vitamin D deficiency in both the general population and at-risk groups. Given the association between vitamin D deficiency and various diseases, addressing this concern becomes crucial, especially in situations where routine monitoring is challenging. MATERIALS AND METHODS: A systematic literature review of the current knowledge on vitamin D dosing in diverse at-risk populations and the application of the findings to a broader clinical perspective. RESULTS: The reviewed studies revealed a high prevalence of vitamin D deficiency among patients with musculoskeletal disorders, systemic connective tissue diseases, corticosteroid use, endocrine and metabolic conditions, malabsorption syndromes, obesity, chronic kidney disease, cancer, and central nervous system diseases. Vitamin D deficiency was often more severe compared to the general population. Higher dosages of vitamin D beyond the recommended levels for the general population were shown to be effective in improving vitamin D status in these at-risk individuals. Additionally, some studies suggested a potential link between intermittent vitamin D administration and improved adherence. CONCLUSION: Simplified dosing could empower clinicians to address vitamin D deficiency, particularly in high-risk populations, even without routine monitoring. Further research is needed to establish the optimal dosing regimens for specific at-risk populations.

Key Findings

The reviewed studies revealed a high prevalence of vitamin D deficiency among patients with musculoskeletal disorders, systemic connective tissue diseases, corticosteroid use, endocrine and metabolic conditions, malabsorption syndromes, obesity, chronic kidney disease, cancer, and central nervous system diseases. Vitamin D deficiency was often more severe compared to the general population. Higher dosages of vitamin D beyond the recommended levels for the general population were shown to be effe

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population musculoskeletal disorders
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Vitamin D
  • Vitamins
  • Vitamin D Deficiency
  • Knowledge
  • Malabsorption Syndromes

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09