Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review

source extracted confidence: high 2026-04-09
#humans #amyloid-beta-peptides #acetylcholinesterase #berberine #alzheimer-disease

Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review

Singh et al., 2023 | Chem Biol Drug Des | Systematic Review

Citation

Singh Yash Pal, Kumar Harish. Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review. Chem Biol Drug Des. 2023-Dec;102(6):1592-1603. doi:10.1111/cbdd.14337

Abstract

Alzheimer's disease (AD) is a chronic age-related neurodegenerative brain disorder characterized by the impairment of memory accompanied by worsening of thinking ability of an individual. The exact pathophysiology of AD is not fully understood. However low level of the neurotransmitter named acetylcholine (ACh), aggregation of Aβ peptide into toxic Aβ plaque, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress are the main hallmarks of this disease. Due to the complex pathophysiology of AD, no specific treatment is available in the market, and treatment is only limited to the symptomatic relief. So, there is an urgent need for the development of new drug candidate, which can have disease-modifying effect and improve learning and memory in AD patient. Therefore, berberine-based multifunction compounds with potential cholinesterase inhibitory properties were reviewed in this article. Structure-activity relationship (SAR) and biological activity provide highlights on the new derivatives used for the management of AD.

Key Findings

Structure-activity relationship (SAR) and biological activity provide highlights on the new derivatives used for the management of AD.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Humans
  • Amyloid beta-Peptides
  • Acetylcholinesterase
  • Berberine
  • Alzheimer Disease
  • Oxidative Stress
  • Cholinesterase Inhibitors

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: berberine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09