The effect of vitamin C on oxidative stress indices and skin regimentation of vitiligo patients

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#humans #vitiligo #ascorbic-acid #iran #skin

The effect of vitamin C on oxidative stress indices and skin regimentation of vitiligo patients

Fallah et al., 2023 | Arch Dermatol Res | Rct

Citation

Fallah Maryam, Abedini Robabeh, ... Ebrahimpour-Koujan Soraiya. The effect of vitamin C on oxidative stress indices and skin regimentation of vitiligo patients. Arch Dermatol Res. 2023-Nov;315(9):2655-2660. doi:10.1007/s00403-023-02687-2

Abstract

It has been suggested that vitamin C is involved in suppressing stress oxidation signaling in vitiligo disease. However, the effect of vitamin C supplementation on stress oxidative factors has not been investigated in vitiligo subjects. This study was designed to examine the effects on vitamin C supplementation on serum levels of stress oxidative factors and regimentation in vitiligo patients. Forty-four vitiligo patients will be recruited in this study. After block matching for sex and number of phototherapy sessions, they will be randomly assigned to receive 1000 mg/d vitamin C or placebo for 8 weeks. The weight, height, and waist circumference of participants will be measured. Determination of serum stress oxidative indices (CAT, SOD, GPX, MDA, TOS, TAC) will be done at study baseline and at the end of the trial. Also, the regimentation will be determined using the VASI score. This is the first randomized controlled trial that will determine the effect of vitamin C supplementation on serum levels of stress oxidative indices and regimentation in vitiligo patients. The results of this trial will provide clinical evidence on the effectiveness of vitamin C supplementation in controlling oxidative stress in vitiligo patients. Trial registration number: This study is registered in the Iranian Registry of Clinical Trials website (available at http://www.irct.ir , identifier: IRCT20230123057193N1), Registration date: 2023/04/17.

Key Findings

Trial registration number: This study is registered in the Iranian Registry of Clinical Trials website (available at http://www.irct.ir , identifier: IRCT20230123057193N1), Registration date: 2023/04/17.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Humans
  • Vitiligo
  • Ascorbic Acid
  • Iran
  • Skin
  • Hypopigmentation
  • Oxidative Stress

Evidence Classification

  • Level: Rct
  • Publication Types: Randomized Controlled Trial, Journal Article
  • Vertical: vitamin-c-skin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09