A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein

source extracted confidence: high 2026-04-09
#humans #c-reactive-protein #selenium #dietary-supplements #inflammation

A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein

Gholami et al., 2023 | J Trace Elem Med Biol | Meta Analysis

Citation

Gholami Ali, Amirkalali Bahareh, ... Hariri Mitra. A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein. J Trace Elem Med Biol. 2023-Dec;80:127273. doi:10.1016/j.jtemb.2023.127273

Abstract

BACKGROUND: Despite conducting new studies on the potential effect of selenium in reducing inflammation; results held contradictory weights and turns into an intriguing area of research. Concerns have been raised on this matter on hand to reach conclusive/consistent results. Therefore, this study seeks to address this scientific gap by assessing randomized controlled trials (RCTs) investigating the effect of selenium intake on C-reactive protein (CRP). METHOD AND MATERIALS: To find all the relevant English-language RCTs, databases including SCOPUS, Web of Science, Clinical Trials.gov, PubMed, and Cochrane Library were searched with no time limit (up to June 2022). Based on the mean changes for both comparison and intervention groups, the effect sizes were calculated. Further, DerSimonian and Laird random-effects model was performed to determine the summary of overall effects and their heterogeneity. RESULTS: Fifteen studies were selected for systematic review and thirteen studies were known to be eligible for meta-analysis. Meta-analysis results indicated a significant effect in serum CRP concentrations compared to the control group (weighted mean difference (WMD)= -0.22 mg/L 95 % confidence interval (CI): - 0.39, - 0.04; p = 0.014). CONCLUSION: In conclusion, our study confirms the downward effect of selenium on the serum concentration of CRP. On a wider level, further research is also needed to assess the selenium effect on other inflammatory mediators.

Key Findings

Fifteen studies were selected for systematic review and thirteen studies were known to be eligible for meta-analysis. Meta-analysis results indicated a significant effect in serum CRP concentrations compared to the control group (weighted mean difference (WMD)= -0.22 mg/L 95 % confidence interval (CI): - 0.39, - 0.04; p = 0.014).

Outcomes Measured

  • C-reactive protein
  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition inflammation

MeSH Terms

  • Humans
  • C-Reactive Protein
  • Selenium
  • Dietary Supplements
  • Inflammation
  • Inflammation Mediators
  • Biomarkers
  • Randomized Controlled Trials as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Systematic Review, Meta-Analysis, Journal Article
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09