Vitamin D and gastric cancer - A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #vitamin-d #lymphatic-metastasis #stomach-neoplasms #neoplasm-staging

Vitamin D and gastric cancer - A systematic review and meta-analysis

Zhao et al., 2023 | Nutr Hosp | Meta Analysis

Citation

Zhao Xi, Wang Jie, Zou Long. Vitamin D and gastric cancer - A systematic review and meta-analysis. Nutr Hosp. 2023-Oct-06;40(5):1080-1087. doi:10.20960/nh.04410

Abstract

Objective: to explore the association between serum vitamin D level and the occurrence and pathological grade of gastric cancer. Material a nd methods: search PubMed, Embase, Web of Science, Cochrane and Chinese database; all articles about the association between serum vitamin D levels and gastric cancer published before July 2021. Results: 10 trials with 1159 cases of gastric cancer patients and 33,387 cases of regular control patients were analyzed. The serum vitamin D level of the gastric cancer group (15.56 ± 7.46 ng/ml) was lower than in the control group (17.60 ± 1.61 ng/ml), and the difference was statistically significant. The patients with gastric cancer, clinical stage III/IV (16.19 ± 8.04 ng/ml) had lower vitamin D levels than those with stage I/II (19.61 ± 9.61 ng/ml), and the patients with low differentiation of gastric cancer (17.5 ± 9.5 ng/ml) had lower levels than those with well- or moderately-differentiated cancer (18.04 ± 7.92 ng/ml). The patients with lymph node metastasis (19.41 ± 8.63 ng/ml) had lower vitamin D levels than the patients without lymph node metastasis (20.65 ± 7.96 ng/ml), and the difference was statistically significant. Conclusion: vitamin D levels were negatively associated with gastric cancer. Vitamin D levels were significantly associated with different clinical stages, degrees of differentiation, and lymph node metastasis, suggesting that low vitamin D levels might predict poor prognosis in gastric cancer.

Key Findings

10 trials with 1159 cases of gastric cancer patients and 33,387 cases of regular control patients were analyzed. The serum vitamin D level of the gastric cancer group (15.56 ± 7.46 ng/ml) was lower than in the control group (17.60 ± 1.61 ng/ml), and the difference was statistically significant. The patients with gastric cancer, clinical stage III/IV (16.19 ± 8.04 ng/ml) had lower vitamin D levels than those with stage I/II (19.61 ± 9.61 ng/ml), and the patients with low differentiation of gastri

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population gastric cancer
Sample Size 10
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Vitamin D
  • Lymphatic Metastasis
  • Stomach Neoplasms
  • Neoplasm Staging
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: vitamin-d-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09