Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review

source extracted confidence: high 2026-04-09

Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review

Amiri et al., 2023 | Front Med (Lausanne) | Systematic Review

Citation

Amiri Mojgan, Meçani Renald, ... Muka Taulant. Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review. Front Med (Lausanne). 2023;10:1195934. doi:10.3389/fmed.2023.1195934

Abstract

INTRODUCTION: Calcium Hydroxylapatite (CaHA) is a common dermal filler used in aesthetic medicine for volumizing and contouring. Understanding mechanisms of actions of CaHA can help improve our understanding of its clinical applications. METHODS: We performed a systematic review to summarize the skin-regeneration related mechanisms of CaHA. Five bibliographic databases were searched for English-language publications that evaluated CaHA in skin regeneration outcomes including neocollagenesis, cell proliferation and growth factors, angiogenesis, vascular dynamic and inflammatory markers, among others. Methodological rigor of included studies was assessed. RESULTS: Of 2,935 identified citations, 12 studies were included for final analysis. Collagen production was reported by nine studies, cell proliferation by four, elastic fibers and/or elastin by four, and three studies on angiogenesis, while limited studies were available on the other outcomes. Six were clinical/observational studies. Only seven studies had a control group. Overall, studies showed CaHA resulted in increased cell proliferation, increased collagen production and angiogenesis, as well as in higher elastic fiber and elastin formation. Limited and inconclusive evidence was available on the other mechanisms. The majority of the studies had methodological limitations. DISCUSSION: Current evidence is limited but indicates several mechanisms through which CaHA could lead to skin regeneration, volume enhancement, and contouring. SYSTEMATIC REVIEW REGISTRATION: https://doi.org/10.17605/OSF.IO/WY49V.

Key Findings

Of 2,935 identified citations, 12 studies were included for final analysis. Collagen production was reported by nine studies, cell proliferation by four, elastic fibers and/or elastin by four, and three studies on angiogenesis, while limited studies were available on the other outcomes. Six were clinical/observational studies. Only seven studies had a control group. Overall, studies showed CaHA resulted in increased cell proliferation, increased collagen production and angiogenesis, as well as i

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 12
Age Range See abstract
Condition See abstract

MeSH Terms

  • No MeSH terms indexed

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09