Melatonin supplementation improves rheumatological disease activity: A systematic review
Melatonin supplementation improves rheumatological disease activity: A systematic review
de et al., 2023 | Clin Nutr ESPEN | Systematic Review
Citation
de Carvalho Jozélio Freire, Skare Thelma L. Melatonin supplementation improves rheumatological disease activity: A systematic review. Clin Nutr ESPEN. 2023-Jun;55:414-419. doi:10.1016/j.clnesp.2023.04.011
Abstract
BACKGROUND: Melatonin is a pineal hormone with a complex role. It is linked to sleep, inflammatory, oxidative, and immunological processes. AIM: To review the use of melatonin supplementation in rheumatological diseases. METHODS: A systematic search of PubMed, Embase, and Scielo databases was performed, looking for articles on Melatonin and rheumatic diseases published between 1966 and August 2022. RESULTS: Thirteen articles were identified: in fibromyalgia (n = 5 articles), rheumatoid arthritis (n = 2), systemic sclerosis (n = 1), systemic lupus erythematosus (n = 1) and osteoporosis/osteopenia (n = 3) and osteoarthritis (n = 1). There were positive results of melatonin administration in fibromyalgia, osteoarthritis, and osteoporosis/osteopenia but not in rheumatoid arthritis and lupus. The drug was well tolerated with mild side effects. CONCLUSION: This review shows the efficacy of Melatonin in some rheumatic diseases. However, new studies are needed to elucidate the real role of this treatment in rheumatology.
Key Findings
Thirteen articles were identified: in fibromyalgia (n = 5 articles), rheumatoid arthritis (n = 2), systemic sclerosis (n = 1), systemic lupus erythematosus (n = 1) and osteoporosis/osteopenia (n = 3) and osteoarthritis (n = 1). There were positive results of melatonin administration in fibromyalgia, osteoarthritis, and osteoporosis/osteopenia but not in rheumatoid arthritis and lupus. The drug was well tolerated with mild side effects.
Outcomes Measured
- inflammatory markers
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | 5 |
| Age Range | See abstract |
| Condition | sleep |
MeSH Terms
- Humans
- Fibromyalgia
- Melatonin
- Arthritis, Rheumatoid
- Rheumatic Diseases
- Osteoarthritis
- Osteoporosis
- Dietary Supplements
Evidence Classification
- Level: Systematic Review
- Publication Types: Systematic Review, Journal Article
- Vertical: melatonin
Provenance
- PMID: 37202076
- DOI: 10.1016/j.clnesp.2023.04.011
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09