Metalloproteinases and Hypertrophic Cardiomyopathy: A Systematic Review

Serraino et al., 2023 | Biomolecules | Systematic Review

Citation

Serraino Giuseppe Filiberto, Jiritano Federica, ... Serra Raffaele. Metalloproteinases and Hypertrophic Cardiomyopathy: A Systematic Review. Biomolecules. 2023-Apr-11;13(4). doi:10.3390/biom13040665

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic condition determined by an altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of MMPs profile in patients with HCM. All studies meeting the inclusion criteria (detailed data regarding MMPs in patients with HCM) were selected, after screening the literature from July 1975 to November 2022. Sixteen trials that enrolled a total of 892 participants were included. MMPs-particularly MMP2-levels were found higher in HCM patients compared to healthy subjects. MMPs were used as biomarkers after surgical and percutaneous treatments. Understanding the molecular processes that control the cardiac ECM's collagen turnover allows for a non-invasive evaluation of HCM patients through the monitoring of MMPs and TIMPs.

Key Findings

Understanding the molecular processes that control the cardiac ECM's collagen turnover allows for a non-invasive evaluation of HCM patients through the monitoring of MMPs and TIMPs.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Humans
• Cardiomyopathy, Hypertrophic
• Heart
• Collagen
• Matrix Metalloproteinases

Evidence Classification

• Level: Systematic Review
• Publication Types: Systematic Review, Journal Article
• Vertical: collagen

Provenance

• PMID: 37189412
• DOI: 10.3390/biom13040665
• PMCID: PMC10136246
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09