Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials

source extracted confidence: high 2026-04-09
#humans #thiamine #heart-failure #research-design #dietary-supplements

Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials

Syed et al., 2023 | Heart Lung | Meta Analysis

Citation

Syed Abdul Rehman Shah, Syed Abdul Ahad, ... Kumar Nomesh. Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials. Heart Lung. 2023;61:37-45. doi:10.1016/j.hrtlng.2023.04.011

Abstract

BACKGROUND: Heart failure is a pathophysiological condition where decreased cardiac output is observed subsequent to any structural deformity or cessation of normal function. Thiamine deficiency is one of the risk factors responsible for causing HF; other risk factors include hypertension, smoking, and obesity. OBJECTIVE: We conducted a systemic review and meta-analysis of RCTs to scrutinize whether the heart failure patients would benefit from thiamine supplementation or not when compared to placebo. METHODS: We selected only those double-arm randomized controlled trials (RCTs) which included participants presenting with symptomatic heart failure. We excluded all the articles published in languages other than English Language. Furthermore, all the studies other than RCTs were also omitted. Articles yielded from the electronic search were exported to EndNote Reference Library software to remove any duplicates. Analyses were done using the Review manager 5.4 tool. Mean values and standard deviations were retrieved for the continuous outcomes given as raw data. RESULTS: The 6 RCTs selected for the statistical analysis consisted of 298 participants (158 in the intervention group, 140 in the placebo group). The outcomes resulted to be non-significant with LVEF p-value= 0.08, NT-pro BNP p-value= 0.94, LVEDV p-value= 0.53, 6MWT p-value=0.59, mortality p-value= 0.61, hospitalization p-value= 0.53 and dyspnea p-value= 0.77. Heart rate is the only significant outcome with a p-value=0.04. CONCLUSION: To conclude, except for heart rate, thiamine supplementation had no effect on the outcomes of heart failure patients.

Key Findings

The 6 RCTs selected for the statistical analysis consisted of 298 participants (158 in the intervention group, 140 in the placebo group). The outcomes resulted to be non-significant with LVEF p-value= 0.08, NT-pro BNP p-value= 0.94, LVEDV p-value= 0.53, 6MWT p-value=0.59, mortality p-value= 0.61, hospitalization p-value= 0.53 and dyspnea p-value= 0.77. Heart rate is the only significant outcome with a p-value=0.04.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 298
Age Range See abstract
Condition hypertension

MeSH Terms

  • Humans
  • Thiamine
  • Heart Failure
  • Research Design
  • Dietary Supplements

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: thiamine-heart

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09