Association between diabetes and thiamine status - A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #thiamine #albuminuria #diabetes-mellitus #thiamine-pyrophosphate

Association between diabetes and thiamine status - A systematic review and meta-analysis

Ziegler et al., 2023 | Metabolism | Meta Analysis

Citation

Ziegler Dan, Reiners Karlheinz, ... Obeid Rima. Association between diabetes and thiamine status - A systematic review and meta-analysis. Metabolism. 2023-Jul;144:155565. doi:10.1016/j.metabol.2023.155565

Abstract

BACKGROUND: Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine status is lower in individuals with diabetes compared to individuals with normal glucose metabolism. AIMS: We conducted a systematic review and meta-analysis to study whether the circulating concentrations of various thiamine analytes differ between people with and those without diabetes. METHODS: PubMed and the Cochrane Central Register of Controlled Trials were searched according to the study protocol. The standardized mean difference (SMD) and 95 % confidence intervals (CI) of thiamine markers between individuals with and without diabetes were used as effect size (random effects model). Subgroup analysis considered albuminuria as an additional variable. RESULTS: Out of the 459 articles identified, 24 full-texts were eligible for the study, 20 of which qualified for the data analysis and four were evaluated for coherence. Compared to controls, individuals with diabetes showed lower concentrations of thiamine (pooled estimate SMD [95 % CI]: -0.97 [-1.89, -0.06]), thiamine monophosphate (-1.16 [-1.82, -0.50]), and total thiamine compounds (-1.01 [-1.48, -0.54]). Thiamine diphosphate (-0.72 [-1.54, 0.11] and erythrocyte transketolase activity (-0.42 [-0.90, 0.05]) tended to be lower in persons with diabetes than in controls without reaching statistical significance. Subgroup analysis showed that individuals with diabetes and albuminuria had lower thiamine levels than the controls (-2.68 [-5.34, -0.02]). CONCLUSIONS: Diabetes is associated with lower levels of various thiamine markers, suggesting that individuals with diabetes may have higher thiamine requirements than those without diabetes, but well-designed studies are required to confirm these findings.

Key Findings

Out of the 459 articles identified, 24 full-texts were eligible for the study, 20 of which qualified for the data analysis and four were evaluated for coherence. Compared to controls, individuals with diabetes showed lower concentrations of thiamine (pooled estimate SMD [95 % CI]: -0.97 [-1.89, -0.06]), thiamine monophosphate (-1.16 [-1.82, -0.50]), and total thiamine compounds (-1.01 [-1.48, -0.54]). Thiamine diphosphate (-0.72 [-1.54, 0.11] and erythrocyte transketolase activity (-0.42 [-0.90,

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population diabetes compared to individuals
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Humans
  • Thiamine
  • Albuminuria
  • Diabetes Mellitus
  • Thiamine Pyrophosphate
  • Glucose

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article, Research Support, Non-U.S. Gov't
  • Vertical: thiamine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09