Association of maternal serum magnesium with pre-eclampsia in African pregnant women: a systematic review and meta-analysis

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#female #pregnancy #humans #pre-eclampsia #pregnant-people

Association of maternal serum magnesium with pre-eclampsia in African pregnant women: a systematic review and meta-analysis

Tesfa et al., 2024 | Int Health | Meta Analysis

Citation

Tesfa Endalamaw, Munshea Abaineh, ... Gizaw Solomon Tebeje. Association of maternal serum magnesium with pre-eclampsia in African pregnant women: a systematic review and meta-analysis. Int Health. 2024-Jan-02;16(1):14-22. doi:10.1093/inthealth/ihad026

Abstract

Pre-eclampsia (PE) is a pregnancy-related disorder characterized by hypertension and proteinuria occurring after 20 weeks of gestation. Several studies have been performed to determine the serum magnesium (Mg) level in PE, but most report inconclusive results. Consequently, this study was designed to resolve this controversy among African women. PubMed, Hinari, Google Scholar and African Journals Online electronic databases were searched for studies published in English. The qualities of included articles were appraised using the Newcastle-Ottawa quality assessment tool. Stata 14 software was utilized for analysis and serum Mg levels in cases and normotensive controls were compared through mean and standardized mean difference (SMD) at the 95% confidence interval (CI). In this review, we found that the mean serum Mg level was significantly reduced in cases (0.910±0.762 mmol/L) vs controls (1.167±1.060 mmol/L). The pooled SMD of serum Mg was significantly lower in cases (-1.20 [95% CI -1.64 to -0.75]). Therefore, since serum Mg is reduced in cases vs controls, we propose that Mg is involved in the pathophysiology of PE. Nevertheless, to know the exact mechanisms of Mg in PE development will require large-scale prospective studies.

Key Findings

Nevertheless, to know the exact mechanisms of Mg in PE development will require large-scale prospective studies.

Outcomes Measured

  • serum magnesium levels

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition hypertension

MeSH Terms

  • Female
  • Pregnancy
  • Humans
  • Pre-Eclampsia
  • Pregnant People
  • Magnesium
  • Prospective Studies
  • Pregnancy Complications

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: magnesium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09