Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #zingiber-officinale #lipids #cholesterol-ldl #cholesterol-hdl

Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta-analysis

Salih et al., 2023 | Phytother Res | Meta Analysis

Citation

Salih Alaa Kassar, Alwan Ala Hadi, ... Amerizadeh Atefeh. Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta-analysis. Phytother Res. 2023-Jun;37(6):2472-2483. doi:10.1002/ptr.7769

Abstract

Dyslipidemia is associated with an increased risk of cardiovascular events. Effect of ginger supplementation on lipid profile in humans remains controversial particularly in diabetic patients. A systematic search was performed covering PubMed, Medline, and Scopus, Web of Science (ISI), and Google scholar from January 2010 to January 2022. Inclusion criteria were randomized controlled clinical trials (RCT) study design, at least one of lipid profile components triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) measured before and after ginger consumption. For quantitative data synthesis, a random-effects model was applied. Pooled data showed that ginger intake reduced TC (SMD -0.44; 95% CI: -0.86, -0.02; p = 0.025) and TG (SMD -0.61; 95% CI: -1.14, -0.08; p = 0.024) levels significantly, but it has no significant effect on improving HDL-C (SMD 0.40; 95% CI: -0.01, 0.80; p = 0.057) and LDL-C (SMD -0.34; 95% CI: -0.81, 0.13; p = 0.153). Ginger supplementation decreased TG in obese and diabetic subjects more efficiently. In terms of ginger dose, the result of meta-regression found to be significant only for TC, so that increasing daily doses of ginger reduces TC levels by (β: -0.67; 95% CI: -1.28, -0.07; p = 0.028). Therefore, ginger could be considered as an effective lipid lowering nutraceuticals.

Key Findings

Therefore, ginger could be considered as an effective lipid lowering nutraceuticals.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Zingiber officinale
  • Lipids
  • Cholesterol, LDL
  • Cholesterol, HDL
  • Triglycerides
  • Diabetes Mellitus

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: ginger

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09