Effects of Probiotic and Selenium Co-supplementation on Lipid Profile and Glycemia Indices: A Systematic Review and Meta-analysis of Randomized Clinical Trials

source extracted confidence: high 2026-04-09
#adult #humans #cholesterol #dietary-supplements #probiotics

Effects of Probiotic and Selenium Co-supplementation on Lipid Profile and Glycemia Indices: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Mohammadparast et al., 2023 | Curr Nutr Rep | Meta Analysis

Citation

Mohammadparast Vida, Mohammadi Tanin, ... Mallard Beth L. Effects of Probiotic and Selenium Co-supplementation on Lipid Profile and Glycemia Indices: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Curr Nutr Rep. 2023-Mar;12(1):167-180. doi:10.1007/s13668-023-00448-1

Abstract

PURPOSE OF REVIEW: The current systematic review and meta-analysis was done to evaluate the effects of selenium and probiotic co-supplementation on lipid profile and glycemia indices of the adult population using randomized controlled clinical trials (RCTs). RECENT FINDINGS: Five studies involving 282 participants with a sample size ranging from 38 to 79 were eligible to be enrolled in the current study. Co-supplementation with probiotic and selenium reduced fasting plasma glucose (WMD =  -4.02 mg/dL; 95% CI: -5.87 to -2.18; P < 0.001), insulin (WMD =  -2.50 mIU/mL; 95% CI: -3.11 to -1.90; P < 0.001), homeostatic model assessment for insulin resistance (WMD =  -0.59; 95% CI: -0.74 to -0.43; P < 0.001), quantitative insulin sensitivity check index (WMD = 0.01; 95% CI: 0.01 to 0.02; P < 0.001), total cholesterol (WMD =  -12.75 mg/dL; 95% CI: -19.44 to -6.07; P < 0.001), low-density lipoprotein cholesterol (WMD =  -7.09 mg/dL; 95% CI: -13.45 to -0.73; P = 0.029), and triglyceride (WMD =  -14.38 mg/dL; 95% CI: -23.13 to -5.62; P = 0.001). The findings of the current systematic review and meta-analysis suggested that co-supplementation with probiotics and selenium may benefit adults in terms of glycemia indices and lipid profile. However, due to the small number of included studies, further trials are needed to confirm our findings.

Key Findings

Five studies involving 282 participants with a sample size ranging from 38 to 79 were eligible to be enrolled in the current study. Co-supplementation with probiotic and selenium reduced fasting plasma glucose (WMD =  -4.02 mg/dL; 95% CI: -5.87 to -2.18; P < 0.001), insulin (WMD =  -2.50 mIU/mL; 95% CI: -3.11 to -1.90; P < 0.001), homeostatic model assessment for insulin resistance (WMD =  -0.59; 95% CI: -0.74 to -0.43; P < 0.001), quantitative insulin sensitivity check index (WMD = 0.01; 95% CI

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 282
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Humans
  • Cholesterol
  • Dietary Supplements
  • Probiotics
  • Randomized Controlled Trials as Topic
  • Selenium
  • Triglycerides
  • Lipid Metabolism

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article, Research Support, Non-U.S. Gov't
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09