Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis

source extracted confidence: high 2026-04-09
#humans #male #antioxidants #diet #dietary-supplements

Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis

Loh et al., 2022 | Nutrients | Meta Analysis

Citation

Loh Wei Qi, Youn Jiyoung, Seow Wei Jie. Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis. Nutrients. 2022-Dec-21;15(1). doi:10.3390/nu15010014

Abstract

Vitamin E is a group of antioxidative tocopherols and tocotrienols that play a potential role in chemoprevention. Studies investigating the association between vitamin E and prostate cancer risk have been conflicting. We identified observational and interventional studies examining the association between vitamin E intake and prostate cancer risk from PubMed, EMBASE and the Cochrane Library. A random-effects model was used to perform a meta-analysis and estimate relative risks (RRs) and the corresponding 95% confidence intervals (CIs) of prostate cancer risk according to vitamin E intake. Subgroup analyses were conducted by study design, sample size, study population characteristics, geographical region, and dose of vitamin E intake. The association between dietary (RR = 0.97; 95% CI = 0.92-1.02) and supplemental (RR = 0.99; 95% CI = 0.94-1.04) vitamin E intake on prostate cancer risk was non-significant. In subgroup analyses, supplemental vitamin E was significantly associated with reduced prostate cancer risk in studies in Europe (RR = 0.81, 95% CI = 0.69-0.97). Overall, this meta-analysis demonstrates little evidence for a beneficial effect of vitamin E intake on prostate cancer risk but suggests that there may be some conditions in which supplements could confer a protective effect on prostate cancer risk.

Key Findings

Overall, this meta-analysis demonstrates little evidence for a beneficial effect of vitamin E intake on prostate cancer risk but suggests that there may be some conditions in which supplements could confer a protective effect on prostate cancer risk.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Male
  • Antioxidants
  • Diet
  • Dietary Supplements
  • Prostatic Neoplasms
  • Risk
  • Vitamin E
  • Observational Studies as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Journal Article
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09