Effects of selenium supplementation on glycaemic control markers in healthy rodents: a systematic review and meta-analysis

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#selenium #sodium-selenite #glycemic-control #dietary-supplements #antioxidants

Effects of selenium supplementation on glycaemic control markers in healthy rodents: a systematic review and meta-analysis

Ferreira et al., 2023 | Br J Nutr | Meta Analysis

Citation

Ferreira Rannapaula Lawrynhuk Urbano, de Sousa Ângela Waleska Freire, ... Pedrosa Lucia Fatima Campos. Effects of selenium supplementation on glycaemic control markers in healthy rodents: a systematic review and meta-analysis. Br J Nutr. 2023-Aug-28;130(4):564-574. doi:10.1017/S0007114522003506

Abstract

Overexposure to Se is detrimental to glucose metabolism, mainly because of its pro-oxidant effects and the overexpression of selenoproteins. This systematic review evaluated the effects of Se supplementation on glycaemic control in healthy rodents. The methodology followed the PRISMA. We searched the databases for articles published up to May 2022. The risk of bias and the methodological quality were assessed using the SYRCLE and CAMARADES. The results are presented as meta-analytic estimates of the overall standardised mean difference (SMD) and 95 % CI. Of the 2359 records retrieved, thirteen studies were included, of which eleven used sodium selenite and two used zero-valent Se nanoparticles as supplement. Nine studies were included in the meta-analysis. Generally, the risk of bias was high, and 23·1 % of the studies were of high quality. Supplementation with sodium selenite significantly increased fasting blood glucose (SMD = 2·57 (95 % CI (1·07, 4·07)), I2 = 93·5 % (P = 0·001). Subgroup analyses showed effect size was larger for interventions lasting between 21 and 28 d (SMD = 25·74 (95 % CI (2·29, 9·18)), I2 = 96·1 % (P = 0·001)) and for a dose of 864·7 μg/kg/d of sodium selenite (SMD = 10·26 (95 % CI (2·42, 18·11), I2 = 97·1 % (P = 0·010)). However, it did not affect glutathione peroxidase activity (SMD = 0·60 (95 % CI (-0·71, 1·91)), I2 = 83·2 % (P = 0·37)). The current analysis demonstrated the adverse effects of sodium selenite supplementation on glycaemic control in healthy rodents.

Key Findings

The current analysis demonstrated the adverse effects of sodium selenite supplementation on glycaemic control in healthy rodents.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population healthy rodents
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Selenium
  • Sodium Selenite
  • Glycemic Control
  • Dietary Supplements
  • Antioxidants

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09