Kidney tissue engineering in preclinical models of renal failure: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#animals #tissue-engineering #tissue-scaffolds #vimentin #creatinine

Kidney tissue engineering in preclinical models of renal failure: a systematic review and meta-analysis

Mirmoghtadaei et al., 2022 | Regen Med | Meta Analysis

Citation

Mirmoghtadaei Milad, Khaboushan Alireza Soltani, ... Kajbafzadeh Abdol-Mohammad. Kidney tissue engineering in preclinical models of renal failure: a systematic review and meta-analysis. Regen Med. 2022-Dec;17(12):941-955. doi:10.2217/rme-2022-0084

Abstract

Aim: This study aims to compare the efficacy of tissue engineering for kidney reconstruction. Materials & methods: We searched MEDLINE, EMBASE (May 2021), and reference lists of review articles. Results: 19 articles matched our inclusion criteria. A range of natural, synthetic and hybrid scaffolds with or without incorporating cells/growth factors was investigated in 937 animals. More favorable results were observed with a combination of two or more biomaterials, addition of bioactive moieties, and cell seeding. Creatinine concentration, PAX2, collagen type-1, α-SMA, vimentin, IL-1, IL-6 and TNF-α gene expressions were significantly increased compared with native control. Conclusion: Tissue engineering can improve renal function and regeneration; however, further research could benefit from using hybrid scaffolds, stem cells and large animal models.

Key Findings

19 articles matched our inclusion criteria. A range of natural, synthetic and hybrid scaffolds with or without incorporating cells/growth factors was investigated in 937 animals. More favorable results were observed with a combination of two or more biomaterials, addition of bioactive moieties, and cell seeding. Creatinine concentration, PAX2, collagen type-1, α-SMA, vimentin, IL-1, IL-6 and TNF-α gene expressions were significantly increased compared with native control. Conclusion: Tissue engi

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Tissue Engineering
  • Tissue Scaffolds
  • Vimentin
  • Creatinine
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Biocompatible Materials
  • Kidney
  • Collagen
  • Renal Insufficiency
  • Interleukin-1

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09