Association between serum calcium and hemorrhagic transformation in ischemic stroke: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#brain-ischemia #calcium #fibrinolytic-agents #humans #ischemic-stroke

Association between serum calcium and hemorrhagic transformation in ischemic stroke: A systematic review and meta-analysis

Wang et al., 2022 | J Clin Neurosci | Meta Analysis

Citation

Wang Jiaxin, Li Wei, ... Cao Lei. Association between serum calcium and hemorrhagic transformation in ischemic stroke: A systematic review and meta-analysis. J Clin Neurosci. 2022-Oct;104:107-112. doi:10.1016/j.jocn.2022.08.007

Abstract

BACKGROUND: Hemorrhagic transformation (HT) is a common complication of ischemic stroke. A growing number of studies have found that serum calcium levels are lower in HT groups than in control groups. However, the relationship between serum calcium and HT remains controversial. We performed a meta-analysis to assess the relationship between serum calcium levels and HT. METHODS AND RESULTS: Electronic databases were searched for studies on serum calcium and HT from inception to November 6, 2021. Ten studies included in present meta-analysis with a total of 3212 participants. Due to the high heterogeneity (I2 = 81%), we chose the random effects model. The results showed that the serum calcium level in the HT group was significantly lower than that in the control group (pooled mean difference, -0.05; 95% confidence interval (CI), (-0.09, -0.02); P = 0.001). Whether thrombolytic or not the results were applied (pooled mean difference, -0.07; 95% CI, (-0.13, -0.01); P = 0.02 and pooled mean difference, -0.03; 95% CI, (-0.06, -0.01); P = 0.007). CONCLUSIONS: Serum calcium was related to HT and may be one of the risk factors for HT.

Key Findings

Electronic databases were searched for studies on serum calcium and HT from inception to November 6, 2021. Ten studies included in present meta-analysis with a total of 3212 participants. Due to the high heterogeneity (I2 = 81%), we chose the random effects model. The results showed that the serum calcium level in the HT group was significantly lower than that in the control group (pooled mean difference, -0.05; 95% confidence interval (CI), (-0.09, -0.02); P = 0.001). Whether thrombolytic or no

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 3212
Age Range See abstract
Condition See abstract

MeSH Terms

  • Brain Ischemia
  • Calcium
  • Fibrinolytic Agents
  • Humans
  • Ischemic Stroke
  • Risk Factors
  • Stroke

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: calcium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09