Experimental Evidence for the Anti-Metastatic Action of Ginsenoside Rg3: A Systematic Review

source extracted confidence: high 2026-04-09
#animals #epithelial-mesenchymal-transition #ginsenosides #lung-neoplasms #panax

Experimental Evidence for the Anti-Metastatic Action of Ginsenoside Rg3: A Systematic Review

Oh et al., 2022 | Int J Mol Sci | Systematic Review

Citation

Oh Hyeon-Muk, Cho Chong-Kwan, Son Chang-Gue. Experimental Evidence for the Anti-Metastatic Action of Ginsenoside Rg3: A Systematic Review. Int J Mol Sci. 2022-Aug-13;23(16). doi:10.3390/ijms23169077

Abstract

Cancer metastasis is the leading cause of death in cancer patients. Due to the limitations of conventional cancer treatment, such as chemotherapy, there is a need for novel therapeutics to prevent metastasis. Ginsenoside Rg3, a major active component of Panax ginseng C.A. Meyer, inhibits tumor growth and has the potential to prevent tumor metastasis. Herein, we systematically reviewed the anti-metastatic effects of Rg3 from experimental studies. We searched for articles in three research databases, MEDLINE (PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) through March 2022. In total, 14 studies (eight animal and six in vitro) provide data on the anti-metastatic effects of Rg3 and the relevant mechanisms. The major anti-metastatic mechanisms of Rg3 involve cancer stemness, epithelial mesenchymal transition (EMT) behavior, and angiogenesis. Taken together, Rg3 would be one of the herbal resources in anti-metastatic drug developments through further well-designed investigations and clinical studies. Our review provides valuable reference data for Rg3-derived studies targeting tumor metastasis.

Key Findings

Our review provides valuable reference data for Rg3-derived studies targeting tumor metastasis.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 14
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Epithelial-Mesenchymal Transition
  • Ginsenosides
  • Lung Neoplasms
  • Panax

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09