Anti-Toxoplasma gondii Activity of Curcumin: A Systematic Review of Pre-clinical Studies

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#animals #curcumin #toxoplasma #rats

Anti-Toxoplasma gondii Activity of Curcumin: A Systematic Review of Pre-clinical Studies

Kalani et al., 2023 | Infect Disord Drug Targets | Systematic Review

Citation

Kalani Hamed, Shakib Pegah, ... Zivdaria Masoomeh. Anti-Toxoplasma gondii Activity of Curcumin: A Systematic Review of Pre-clinical Studies. Infect Disord Drug Targets. 2023;23(2):e200822207821. doi:10.2174/1871526522666220820185637

Abstract

OBJECTIVE: This study has focused on anti-Toxoplasma gondii activity of curcumin. METHODS: In this systematic review, anti-parasitic activity of Curcuma longa on Toxoplasma gondii was assessed. Therefore, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar, were searched from 2010 to 2020. RESULTS: Of the 2200 papers retrieved between 2010 and 2020, six articles were reliable and were scrutinized. In 2 in vitro studies, the most used strain was the RH strain of Toxoplasma gondii, whereas among 4 in vivo studies, RH strain was found in 2 (50%) studies, Me49 strain in 1(25%) study, and RH and Me49 strain in 1 (25%) study. In four in vivo studies, the most used animal model was BALB/c, and Swiss albino was found in 1 study (25%) and Albino rats in 1 study (25%). CONCLUSION: Curcumin and nanoparticles formulated with curcumin are new and useful agents for the treatment of parasitic diseases and reduction of drug resistance. The success of this therapeutic approach stems from the specific action of Curcuma longa against parasites and pathogens.

Key Findings

Of the 2200 papers retrieved between 2010 and 2020, six articles were reliable and were scrutinized. In 2 in vitro studies, the most used strain was the RH strain of Toxoplasma gondii, whereas among 4 in vivo studies, RH strain was found in 2 (50%) studies, Me49 strain in 1(25%) study, and RH and Me49 strain in 1 (25%) study. In four in vivo studies, the most used animal model was BALB/c, and Swiss albino was found in 1 study (25%) and Albino rats in 1 study (25%).

Outcomes Measured

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Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Curcumin
  • Toxoplasma
  • Rats

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09