Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?

source extracted confidence: high 2026-04-09
#humans #antioxidants #friends #dietary-supplements #exercise

Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?

Wang et al., 2023 | J Cardiovasc Transl Res | Meta Analysis

Citation

Wang Hongyun, Yang Zijiang, ... Xiao Junjie. Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?. J Cardiovasc Transl Res. 2023-Feb;16(1):51-62. doi:10.1007/s12265-022-10297-y

Abstract

Exercise is a preferred strategy for improving cardiac function, especially for patients with cardiovascular diseases. Increasing evidence indicates that oxidative stress is involved in exercise-induced cardioprotection, while the underlying mechanism remains unclear. Furthermore, the effect of antioxidant supplementation during or post-exercise still exists despite divergences. To explore the effect of oxidative stress and antioxidant supplementation on cardiovascular homeostasis during or post-exercise, we take insights into the progress of exercise-induced oxidative stress, antioxidant supplementation, and cardiovascular homeostasis. In particular, antioxidants such as vitamin C or E, gamma-oryzanol, and other natural antioxidants are discussed concerning regulating exercise-associated oxidative stress. Additionally, our present study reviewed and discussed a meta-analysis of antioxidant supplementation during exercise. Overall, we take an insight into the essential biological adaptations in response to exercise and the effects of antioxidant supplementation on cardiac function, which aid us in giving recommendations on antioxidant supplementation for exercisers and exercised people. A better understanding of these issues will broaden our knowledge of exercise physiology.

Key Findings

A better understanding of these issues will broaden our knowledge of exercise physiology.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population cardiovascular diseases
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Humans
  • Antioxidants
  • Friends
  • Dietary Supplements
  • Exercise
  • Oxidative Stress
  • Homeostasis

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Journal Article, Review, Research Support, Non-U.S. Gov't
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09