Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review

source extracted confidence: high 2026-04-09
#arthritis-rheumatoid #collagen #collagen-type-ii #dietary-supplements #humans

Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review

Jabbari et al., 2022 | Int J Rheum Dis | Systematic Review

Citation

Jabbari Masoumeh, Barati Meisam, ... Eini-Zinab Hassan. Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review. Int J Rheum Dis. 2022-Sep;25(9):973-981. doi:10.1111/1756-185X.14382

Abstract

Rheumatoid arthritis (RA) and osteoarthritis (OA) both are chronic diseases affecting joints. Immune response against collagen in both diseases may have a role in the initiation and progression of the disease. There is a hypothesis that suppression of immune response vs collagen could be a therapeutic approach in RA and OA. Exposure of gut immune system to collagen is a way to suppress immune response against collagen in the joints. So, the current systematic review is aimed to evaluate the effects of collagen supplementation in OA and RA patients. In the current systematic review, online electronic databases including PubMed/MEDLINE, Web of Sciences and Scopus were searched and finally 19 articles were included. The enrolled articles evaluated the effects of collagen supplementation on treatment of OA (n = 9) and RA (n = 10). Intact (n = 4) and hydrolyzed (n = 5) collagen were used to treat OA. All of the studies on RA used intact and type II collagen in their intervention. The last trials on collagen supplementation in RA and OA patients were performed in 2011 and 2016, respectively. High adverse effects of collagen supplementation and its low efficiency compared to routine treatments were reported by several included studies. Also, risk of bias assessment showed that most of the studies had poor quality. Therefore, it is not possible to definitely decide on the beneficial or detrimental effects of collagen supplementation on OA and RA patients. Further studies are needed to reach a final decision.

Key Findings

Further studies are needed to reach a final decision.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 9
Age Range See abstract
Condition See abstract

MeSH Terms

  • Arthritis, Rheumatoid
  • Collagen
  • Collagen Type II
  • Dietary Supplements
  • Humans
  • Osteoarthritis

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09