The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

source extracted confidence: high 2026-04-09
#bariatric-surgery #calcifediol #dietary-supplements #humans #obesity-morbid

The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

Mokhtari et al., 2022 | Obes Surg | Meta Analysis

Citation

Mokhtari Zeinab, Hosseini Elham, ... Askari Gholamreza. The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials. Obes Surg. 2022-Sep;32(9):3088-3103. doi:10.1007/s11695-022-06121-w

Abstract

Currently, there is no consensus on the optimal vitamin D administration in bariatric patients. The present systematic review and meta-analysis were conducted to examine the effect of vitamin D supplements on serum level of 25(OH) vitamin D in the patients undergoing bariatric surgery (BS).Random model effects were used to estimate standardized mean difference (SMD) with a 95% confidence interval (CI). Nine clinical trials were included in the meta-analysis. Vitamin D supplementation in patients undergoing BS modestly improves vitamin D status (SMD, 0.53; 95% CI, 0.28, 0.77) particularly, in the dosages above 2850 IU/day and in the patients with BMI greater than 50 kg/m2. Vitamin D supplementation was associated with prevention of raising of the PTH serum concentration and without impact on serum calcium levels.

Key Findings

Vitamin D supplementation was associated with prevention of raising of the PTH serum concentration and without impact on serum calcium levels.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population bmi greater than 50
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Bariatric Surgery
  • Calcifediol
  • Dietary Supplements
  • Humans
  • Obesity, Morbid
  • Randomized Controlled Trials as Topic
  • Vitamin D
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review, Research Support, Non-U.S. Gov't
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09