THE EFFECT OF COENZYME Q10 ON PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS

source extracted confidence: high 2026-04-09
#humans #periodontitis #ubiquinone

THE EFFECT OF COENZYME Q10 ON PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS

Rasoolzadeh et al., 2022 | J Evid Based Dent Pract | Meta Analysis

Citation

Rasoolzadeh Elaheh Akhavan, Shidfar Farzad, ... Hezaveh Zohreh Sajadi. THE EFFECT OF COENZYME Q10 ON PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS. J Evid Based Dent Pract. 2022-Jun;22(2):101710. doi:10.1016/j.jebdp.2022.101710

Abstract

OBJECTIVE: Coenzyme Q10 gel might be beneficial for periodontitis. However, the results have been controversial. We designed a systematic review and meta-analysis to explore the efficacy of coenzyme Q10 in periodontitis patients. MATERIALS AND METHODS: A systematic review of controlled trials (PROSPERO: CRD42020212424) was performed from 1980 to August 2020 by 2 separate investigators through the following databases: Embase, CENTRAL, PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and ProQuest. Hand search of reference lists of the included studies was also performed. Of 269 records, eleven trials were included in the meta-analysis using a random-effect model. RESULTS: Coenzyme Q10 could significantly reduce Plaque Index (SMD, -0.64; CI, -1.03 to -0.26, P = .002; I2 = 85.7%), Bleeding Index (SMD, -1.05; CI, -1.70 to -0.41, P = .001; I2 = 89.5%), Pocket Depth (SMD, -0.96; CI, -1.35 to -0.58, P ˂ .001, I2 = 84.7%), clinical attachment level (SMD, -0.73; CI, -1.23 to -0.22, P = .005; I2 = 87.8%), and gingival index (SMD, -0.63; CI, -0.97 to -0.28, P = .001; I2 = 72.8%) in periodontitis. Subgroup analysis showed that coenzyme Q10 had a stronger reduction effect if administered intra-pocket rather than topical. Studies with high risk of bias reported a greater positive effect of coenzyme Q10 compared to studies with unclear risk. CONCLUSIONS: Our findings encourage administration of coenzyme Q10 gel in periodontitis based on its meaningful effect on Plaque Index, Bleeding Index, gingival index, clinical attachment level and Pocket Depth. Future studies with better qualities are required for a better conclusion.

Key Findings

Coenzyme Q10 could significantly reduce Plaque Index (SMD, -0.64; CI, -1.03 to -0.26, P = .002; I2 = 85.7%), Bleeding Index (SMD, -1.05; CI, -1.70 to -0.41, P = .001; I2 = 89.5%), Pocket Depth (SMD, -0.96; CI, -1.35 to -0.58, P ˂ .001, I2 = 84.7%), clinical attachment level (SMD, -0.73; CI, -1.23 to -0.22, P = .005; I2 = 87.8%), and gingival index (SMD, -0.63; CI, -0.97 to -0.28, P = .001; I2 = 72.8%) in periodontitis. Subgroup analysis showed that coenzyme Q10 had a stronger reduction effect if

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Periodontitis
  • Ubiquinone

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: coq10

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09