Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight

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#amp-activated-protein-kinases #alkaloids #anti-inflammatory-agents #antioxidants #berberine

Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight

Saklani et al., 2022 | Mol Biol Rep | Systematic Review

Citation

Saklani Priyanka, Khan Heena, ... Grewal Amarjot Kaur. Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight. Mol Biol Rep. 2022-Oct;49(10):10101-10113. doi:10.1007/s11033-022-07594-9

Abstract

INTRODUCTION: Neurodegenerative disorders are a diverse variety of diseases that can be distinguished from developing degeneration of neurons in the CNS. Several alkaloids have shown mounting effects in neurodegenerative disorders, and berberine is one of them. Demethyleneberberine is a metabolite of berberine that has better blood-brain barrier crossing capacity. Demethyleneberberine possesses anti-inflammatory, anti-oxidant, and mitochondrial targeting properties. However, neither the pharmacological action nor the molecular mechanism of action of demethyleneberberine on neurodegenerative disorders has been explored yet. MATERIALS AND METHODS: A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elseveier) databases was carried out with the help of keywords like "Demethyleneberberine; neuroinflammation; oxidative stress; Neuroprotective; Neurodegenerative disorders" till date. CONCLUSION: This review focus on the neuroprotective potential of demethyleneberberine in neurodegenerative disorders by attenuating different pathways, i.e., NF-κB, MAPK, and AMPK signalling.

Key Findings

This review focus on the neuroprotective potential of demethyleneberberine in neurodegenerative disorders by attenuating different pathways, i.e., NF-κB, MAPK, and AMPK signalling.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • AMP-Activated Protein Kinases
  • Alkaloids
  • Anti-Inflammatory Agents
  • Antioxidants
  • Berberine
  • Humans
  • NF-kappa B
  • Neurodegenerative Diseases
  • Neuroprotective Agents

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: berberine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09