Preclinical evidence of the effect of quercetin on diabetic nephropathy: A meta-analysis of animal studies

source extracted confidence: high 2026-04-09
#animals #antioxidants #diabetes-mellitus #diabetic-nephropathies #inflammation

Preclinical evidence of the effect of quercetin on diabetic nephropathy: A meta-analysis of animal studies

Feng et al., 2022 | Eur J Pharmacol | Meta Analysis

Citation

Feng Xiao, Bu Fan, ... Wu Quan. Preclinical evidence of the effect of quercetin on diabetic nephropathy: A meta-analysis of animal studies. Eur J Pharmacol. 2022-Apr-15;921:174868. doi:10.1016/j.ejphar.2022.174868

Abstract

Quercetin, which is present in numerous fruits and vegetables, has shown promise in improving inflammation, lipid profiles, and blood pressure in humans. However, the efficacy of quercetin in diabetic nephropathy (DN) remains preclinical and unclear. Therefore, a meta-analysis based on preclinical animal data is needed to assess the efficacy, optimal dosage, and underlying mechanism of DN treatment to accelerate new drug research and clinical translation. We conducted a literature search in PubMed, Embase, Web of Science, and Cochrane Library to retrieve randomized controlled trials evaluating the effects of quercetin in rat or mouse diabetic models. We assessed the quality of the studies individually according to SYRCLE's risk of bias tool for animal studies. Twenty animal studies, including 378 animals, were included in the meta-analysis. Meta-analysis data showed that renal function indices, such as renal index, urine protein, uric acid, urine albumin, and serum creatinine levels, significantly improved with quercetin administration. However, no significant association was observed between quercetin and creatinine clearance. Quercetin remarkably alleviated oxidative stress by reducing malondialdehyde (MDA) and increasing superoxide dismutase (SOD) and catalase (CAT) activities. In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-α（TNF-α）and interleukin-1β（IL-1β）levels. Subgroup analysis performed using quercetin doses and animal species indicated that animal species were a source of heterogeneity. This meta-analysis suggests that quercetin is a promising drug for DN treatment, facilitating clinical prediction and therapy.

Key Findings

This meta-analysis suggests that quercetin is a promising drug for DN treatment, facilitating clinical prediction and therapy.

Outcomes Measured

  • blood pressure
  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Animals
  • Antioxidants
  • Diabetes Mellitus
  • Diabetic Nephropathies
  • Inflammation
  • Mice
  • Oxidative Stress
  • Quercetin
  • Rats

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: quercetin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09