In Vivo and In Vitro Anti-schistosomiasis Effect of Garlic: A Systematic Review

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#animals #antioxidants #biological-products #garlic #plant-extracts

In Vivo and In Vitro Anti-schistosomiasis Effect of Garlic: A Systematic Review

Shakib et al., 2022 | Curr Drug Discov Technol | Systematic Review

Citation

Shakib Pegah, Kalani Hamed, ... Cheraghipour Kourosh. In Vivo and In Vitro Anti-schistosomiasis Effect of Garlic: A Systematic Review. Curr Drug Discov Technol. 2022;19(4):e280222201511. doi:10.2174/1570163819666220228154752

Abstract

BACKGROUND: Garlic (Allium sativum) is used as a natural supplement for the treatment of various diseases and disorders because it has antibacterial, antiviral, antifungal, antiparasitic, antioxidant, and anti-inflammatory properties. This systematic review aimed to evaluate in vitro and in vivo effects of garlic against Schistosoma spp. METHODS: The current study was carried out according to the PRISMA guidelines and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-analysis Facility [SyRF] database. The literature search was conducted using five databases, including Scopus, PubMed, Web of Science, Embase, and Google Scholar, from January 2008 to January 2021. The search was restricted to articles published in the English language. Syntax was performed based on each database tag. RESULTS: Out of 2,600 studies, 10 met the eligibility criteria for review. The examined parasite in all studies was Schistosoma mansoni. Ten studies (90%) were performed in vivo and one study in vitro. Studies have shown that garlic compounds can activate immune system factors, thereby damaging the parasite structure or its eggs. CONCLUSION: Given the increase in using plants in the treatment of many diseases and the fact that plants can be a good alternative to chemical drugs in many cases, more comprehensive research is needed to introduce effective medicinal plants to treat diseases such as schistosomiasis.

Key Findings

Out of 2,600 studies, 10 met the eligibility criteria for review. The examined parasite in all studies was Schistosoma mansoni. Ten studies (90%) were performed in vivo and one study in vitro. Studies have shown that garlic compounds can activate immune system factors, thereby damaging the parasite structure or its eggs.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 2600
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Antioxidants
  • Biological Products
  • Garlic
  • Plant Extracts
  • Schistosoma mansoni
  • Schistosomiasis

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: garlic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09