Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

source extracted confidence: high 2026-04-09
#endoplasmic-reticulum-stress #epithelial-cells #humans #inflammasomes #inflammation

Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

Liu et al., 2022 | Front Immunol | Systematic Review

Citation

Liu Yunlong, Sun Yan, ... Deng Yaoliang. Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis. Front Immunol. 2022;13:818625. doi:10.3389/fimmu.2022.818625

Abstract

Calcium oxalate nephrolithiasis is a common and highly recurrent disease in urology; however, its precise pathogenesis is still unknown. Recent research has shown that renal inflammatory injury as a result of the cell-crystal reaction plays a crucial role in the development of calcium oxalate kidney stones. An increasing amount of research have confirmed that inflammation mediated by the cell-crystal reaction can lead to inflammatory injury of renal cells, promote the intracellular expression of NADPH oxidase, induce extensive production of reactive oxygen species, activate NLRP3 inflammasome, discharge a great number of inflammatory factors, trigger inflammatory cascading reactions, promote the aggregation, nucleation and growth process of calcium salt crystals, and ultimately lead to the development of intrarenal crystals and even stones. The renal tubular epithelial cells (RTECs)-crystal reaction, macrophage-crystal reaction, calcifying nanoparticles, endoplasmic reticulum stress, autophagy activation, and other regulatory factors and mechanisms are involved in this process.

Key Findings

The renal tubular epithelial cells (RTECs)-crystal reaction, macrophage-crystal reaction, calcifying nanoparticles, endoplasmic reticulum stress, autophagy activation, and other regulatory factors and mechanisms are involved in this process.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Endoplasmic Reticulum Stress
  • Epithelial Cells
  • Humans
  • Inflammasomes
  • Inflammation
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nephrolithiasis
  • Reactive Oxygen Species

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Research Support, Non-U.S. Gov't, Systematic Review, Journal Article
  • Vertical: calcium-kidney

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09