Panax ginseng and aging related disorders: A systematic review
Panax ginseng and aging related disorders: A systematic review
de et al., 2022 | Exp Gerontol | Systematic Review
Citation
de Oliveira Zanuso Bárbara, de Oliveira Dos Santos Ana Rita, ... Barbalho Sandra Maria. Panax ginseng and aging related disorders: A systematic review. Exp Gerontol. 2022-May;161:111731. doi:10.1016/j.exger.2022.111731
Abstract
The aging process predisposes numerous homeostatic disorders, metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. Changes in diet and lifestyle and therapeutic adjuvants are essential to minimize the effects of comorbidities associated with aging. Natural products such as Panax ginseng have been used to treat and prevent diseases related to aging. This review aims to investigate the effects of Panax ginseng in various conditions associated with aging, such as inflammation, oxidative stress, mitochondrial dysfunction, apoptosis, neurodegenerative and metabolic disorders, cardiovascular diseases, and cancer. The ginsenosides, chemical constituents found in Panax ginseng, can inhibit the effects of inflammatory cytokines, inhibit signaling pathways that induce inflammation, and inhibit cells that participate in inflammatory processes. Besides, ginsenosides are involved in neuroprotective effects on the central nervous system due to anti-apoptotic, antioxidant, and anti-inflammatory effects. The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function. The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety. Panax ginseng has been shown to exert potent therapeutic benefits that can act as a complementary treatment in managing patients with chronic diseases related to aging.
Key Findings
Panax ginseng has been shown to exert potent therapeutic benefits that can act as a complementary treatment in managing patients with chronic diseases related to aging.
Outcomes Measured
- anxiety
- inflammatory markers
Population
| Field | Value |
|---|---|
| Population | chronic diseases related to |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | anxiety |
MeSH Terms
- Aging
- Ginsenosides
- Humans
- Panax
- Plant Extracts
- Quality of Life
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: ginseng
Provenance
- PMID: 35143871
- DOI: 10.1016/j.exger.2022.111731
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09