Correlation Between Drinking Water and Iodine Status: a Systematic Review and Meta-analysis

source extracted confidence: high 2026-04-09
#humans #iodine #drinking-water #goiter #cross-sectional-studies

Correlation Between Drinking Water and Iodine Status: a Systematic Review and Meta-analysis

Azevedo et al., 2023 | Biol Trace Elem Res | Meta Analysis

Citation

Azevedo Francilene Maria, Machamba Almeida Abudo Leite, ... Franceschini Sylvia do Carmo Castro. Correlation Between Drinking Water and Iodine Status: a Systematic Review and Meta-analysis. Biol Trace Elem Res. 2023-Jan;201(1):129-138. doi:10.1007/s12011-022-03127-4

Abstract

Iodine is a micronutrient essential for maintaining normal body functioning, and the consumption depends on the distribution in the environment, and insufficient or excessive intake results in thyroid dysfunction. The purpose of this review was to evaluate the correlation between iodine concentration in drinking water and the iodine status of the population. The systematic review was conducted following the PRISMA guidelines and was registered at the International Prospective Register of Ongoing Systematic Reviews (CRD42019128308). A literature search was conducted using MEDLINE/PUBMED (National Library of Medicine), LILACS (Latin-American and Caribbean Literature on Health Sciences), and Cochrane Library, June 2021. The quality of the studies was assessed by a checklist for cross-sectional studies developed by Joanna Briggs Institute. The initial search identified 121 articles, out of which ten were included in this systematic review, and five were included in the meta-analysis. Among the articles listed, six adopted cutoff points to classify the iodine content in the drinking water. The study identified median iodine concentration in drinking water from 2.2 to 617.8 μg/L and the correlation between iodine concentration in drinking water and urinary iodine concentration was 0.92, according to meta-analysis. Furthermore, the iodine status was correlated to the iodine content in water. The determination of a cutoff point can contribute to the implementation of iodine consumption control measures.

Key Findings

The determination of a cutoff point can contribute to the implementation of iodine consumption control measures.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Iodine
  • Drinking Water
  • Goiter
  • Cross-Sectional Studies
  • Nutritional Status

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: iodine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09