Nutrients with Antioxidant Properties and Their Effects on Lower-Limb Ulcers: A Systematic Review

source extracted confidence: high 2026-04-09
#humans #antioxidants #wound-healing #dietary-supplements #leg-ulcer

Nutrients with Antioxidant Properties and Their Effects on Lower-Limb Ulcers: A Systematic Review

de et al., 2024 | Int J Low Extrem Wounds | Systematic Review

Citation

de Souza Thamiris, Monteiro Jessyca Dias Cardoso, ... Citelli Marta. Nutrients with Antioxidant Properties and Their Effects on Lower-Limb Ulcers: A Systematic Review. Int J Low Extrem Wounds. 2024-Jun;23(2):217-230. doi:10.1177/15347346221074861

Abstract

Chronic lower-limb ulcers (LLUs) are ulcers that fail to proceed through an orderly and timely process to produce anatomic and functional integrity. LLUs reduce the quality of life of affected individuals and are a public health problem. The treatment options include medications or surgery. Nutrition therapy is an important adjunct to improve the clinical picture and healing of LLUs. Considering that nutrients with antioxidant properties can improve the process of tissue healing, this systematic review aimed to evaluate the efficacy of antioxidant nutrient supplementation in the treatment of LLUs through randomized clinical trials. This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses and the Cochrane Handbook for Systematic Reviews of Interventions. The guiding question was-can antioxidant nutrients help in the treatment of chronic LLUs? In total, 1184 articles were found when searching for antioxidant nutrients associated with the most common causes of LLUs. Fourteen articles were included in this review after removing duplicates, studies with topical and/or venous use of antioxidants, and articles published in other languages, except English. Omega-3 fatty acids, magnesium, zinc, vitamins A, C, D, and resveratrol along with probiotics positively improved the ulcer healing. These effects were more significant when there was initially a deficiency of the respective supplemented nutrients. Therefore, correcting and maintaining an adequate nutritional status can improve ulcer healing and contribute to the clinical treatment of patients with LLUs.

Key Findings

Therefore, correcting and maintaining an adequate nutritional status can improve ulcer healing and contribute to the clinical treatment of patients with LLUs.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population llus
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Antioxidants
  • Wound Healing
  • Dietary Supplements
  • Leg Ulcer
  • Nutrients

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09