Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

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#curcumin #cytokines #dietary-supplements #female #hospitalization

Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Vahedian-Azimi et al., 2022 | Nutrients | Meta Analysis

Citation

Vahedian-Azimi Amir, Abbasifard Mitra, ... Sahebkar Amirhossein. Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials. Nutrients. 2022-Jan-07;14(2). doi:10.3390/nu14020256

Abstract

Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (p < 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.

Key Findings

We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 19
Age Range See abstract
Condition inflammation

MeSH Terms

  • Curcumin
  • Cytokines
  • Dietary Supplements
  • Female
  • Hospitalization
  • Humans
  • Inflammation Mediators
  • Interleukin-10
  • Interleukin-1beta
  • Interleukin-6
  • Interleukins
  • Male
  • Patient Acuity
  • Phytotherapy
  • Transforming Growth Factor alpha
  • Treatment Outcome
  • COVID-19 Drug Treatment

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09