Chinese herbal medicine formula combined with calcium antagonist in the treatment of hypertension: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#antihypertensive-agents #calcium #calcium-channel-blockers #drugs-chinese-herbal #humans

Chinese herbal medicine formula combined with calcium antagonist in the treatment of hypertension: a systematic review and meta-analysis

Zhang et al., 2022 | Clin Exp Hypertens | Meta Analysis

Citation

Zhang Qingyuan, Shao Wenxiang, ... Ao Meiying. Chinese herbal medicine formula combined with calcium antagonist in the treatment of hypertension: a systematic review and meta-analysis. Clin Exp Hypertens. 2022-Feb-17;44(2):181-190. doi:10.1080/10641963.2021.2013491

Abstract

OBJECTIVE: Chinese herbal medicine formula and calcium antagonist are commonly used medicines for hypertension in China. This study aims to examine the efficacy and safety of for the treatment of Chinese herbal medicine formula combined calcium antagonist hypertension. METHODS: PubMed, the Cochrane library, CNKI, VIP, Sinomed, and Wanfang Database were searched up to January 31, 2021. Data analysis was performed using the Recman 5.3. The source of clinical heterogeneity used stata16.0 for sensitivity analysis. RESULTS: 17 RCTs and 1587 cases were finally included. The results shows that the traditional Chinese medicine decoction combined with calcium antagonists is better than calcium antagonists alone in the treatment of hypertension. In addition, it can effectively alleviate the adverse reactions caused by calcium antagonists. However, due to the low quality of methodology and the small-scale research, more high-quality clinical trials are still needed for verification.

Key Findings

17 RCTs and 1587 cases were finally included. The results shows that the traditional Chinese medicine decoction combined with calcium antagonists is better than calcium antagonists alone in the treatment of hypertension. In addition, it can effectively alleviate the adverse reactions caused by calcium antagonists. However, due to the low quality of methodology and the small-scale research, more high-quality clinical trials are still needed for verification.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 17
Age Range See abstract
Condition hypertension

MeSH Terms

  • Antihypertensive Agents
  • Calcium
  • Calcium Channel Blockers
  • Drugs, Chinese Herbal
  • Humans
  • Hypertension

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: calcium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09