Role of dietary patterns and factors in determining the risk of knee osteoarthritis: A meta-analysis

source extracted confidence: high 2026-04-09
#ascorbic-acid #carotenoids #diet #humans #osteoarthritis-knee

Role of dietary patterns and factors in determining the risk of knee osteoarthritis: A meta-analysis

Xu et al., 2022 | Mod Rheumatol | Meta Analysis

Citation

Xu Chao, Wang Shun, ... Shi Song-Qing. Role of dietary patterns and factors in determining the risk of knee osteoarthritis: A meta-analysis. Mod Rheumatol. 2022-Jul-01;32(4):815-821. doi:10.1093/mr/roab059

Abstract

OBJECTIVES: To evaluates the role of diet in determining knee osteoarthritis risk. METHODS: Literature search was conducted in Ovid, PubMed, Science Direct, and Springer. To estimate knee osteoarthritis risk with high use of vegetarian, prudent, and omnivorous diets, dairy products, vitamin C/E, and carotenoids, the odds ratios (ORs) or relative risks (RRs) reported by included studies were pooled. RESULTS: Fifteen studies (97,157 individuals) were included. High use of vegetarian diet {OR 0.71 [95% confidence interval (CI): 0.45, 0.97]}, prudent diet [OR 0.87 (95% CI: 0.76, 0.98)/RR 0.89 (95% CI: 0.82, 0.97)], and dairy [OR 0.66 (95% CI: -0.08, 1.39)/RR 0.58 (95% CI: 0.41, 0.75)] were associated with lower risk of knee osteoarthritis but risk was relatively higher with high use of omnivorous diet [OR 1.13 (95% CI: 0.95, 1.30)/RR 1.06 (95% CI: 0.84, 1.29) and 1.05 (0.78, 1.33)]. High intake of vitamin C [OR 0.92 (0.29, 1.56)] or E [OR 0.93 (0.64, 1.21)] did not reduce knee osteoarthritis risk, but high use of carotenoids was associated with the lower risk [OR 0.66 (0.37, 0.96)]. CONCLUSIONS: Knee osteoarthritis risk is low with high use of vegetarian diet, prudent diet, and dairy, but cannt be reduced by high intakes of vitamin C/E.

Key Findings

Fifteen studies (97,157 individuals) were included. High use of vegetarian diet {OR 0.71 [95% confidence interval (CI): 0.45, 0.97]}, prudent diet [OR 0.87 (95% CI: 0.76, 0.98)/RR 0.89 (95% CI: 0.82, 0.97)], and dairy [OR 0.66 (95% CI: -0.08, 1.39)/RR 0.58 (95% CI: 0.41, 0.75)] were associated with lower risk of knee osteoarthritis but risk was relatively higher with high use of omnivorous diet [OR 1.13 (95% CI: 0.95, 1.30)/RR 1.06 (95% CI: 0.84, 1.29) and 1.05 (0.78, 1.33)]. High intake of vita

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 97157
Age Range See abstract
Condition See abstract

MeSH Terms

  • Ascorbic Acid
  • Carotenoids
  • Diet
  • Humans
  • Osteoarthritis, Knee
  • Risk Factors
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09